Chasing pain : the search for a neurobiological mechanism / Kenneth L. Casey.

Format:

Book

Author/Creator:

Casey, Kenneth L. (Kenneth Lyman), 1935- author.

Contributor:

William Pepper Medical Library Fund.

Oxford University Press.

Language:

English

Subjects (All):

Pain.

Pain--Treatment.

Pain Management.

Medical Subjects:

Pain.

Pain Management.

Physical Description:

1 online resource : illustrations

polychrome

Other Title:

Subtitle on publisher web site: search for a neurobiological mechanism of pain

Search for a neurobiological mechanism

Place of Publication:

New York : Oxford University Press, [2019]

System Details:

text file

Contents:

1 A Sample at the Extremes p. 5

Pain Without Tissue Damage p. 5

Causalgia p. 5

Migraine p. 5

Central Pain p. 6

Tissue Damage Without Pain p. 7

Sports and Ritual Analgesia p. 7

Surgery Without Anesthesia p. 8

Summarizing this Sample of Pain-Related Experiences p. 14

2 Drivers of Pain Research and a Meeting in Issaquah p. 16

Medicine p. 16

Neuroscience p. 16

Philosophy p. 17

A Meeting in Issaquah p. 17

Conceptual Models of Pain at Issaquah (1973) p. 19

3 Functional Localization, the Spinothalamic Tract, and Neurosurgery for Pain p. 21

Functional Localization p. 21

The Spinothalamic Tract p. 22

Neurosurgery for Pain Revisited p. 27

4 Emotions, Affect, and the Limbic System p. 31

Sherrington and Pseudaffective Reflexes p. 31

Bard and Sham Rage p. 32

Papez and the Emotional Brain p. 32

Pain: A Synthetic Experience and a New Conceptual Model p. 34

5 Early Evidence of Central Nervous System Control and a Conceptual Model Revisited p. 40

Anatomy p. 40

Neurophysiology p. 42

Neuropharmacology p. 43

Progress Since the Issaquah Meeting p. 44

6 Psychophysics and Nociceptors p. 46

Psychophysics p. 46

Nociceptors and Their Fibers p. 48

Psychophysical Neuronography p. 49

Inflammatory Excitation of Nociceptors and Neurogenic Inflammation p. 53

7 Central Sensitization and Pain Genes p. 58

Central Sensitization p. 58

Genetics and Ion Channels p. 60

8 Central Nervous System Modulation of Pain: Neurophysiological and Clinical Evidence p. 63

Some Analgesia Circuits p. 63

The Periaqueductal Gray Connection p. 64

Diffuse Noxious Inhibitory Control p. 66

Stimulating Analgesia Circuits in Humans p. 67

Stimulating Pain Generation Circuits in Humans p. 68

Electrophysiological Identification of Pain-Related Circuits p. 69

When Control Breaks Down p. 72

9 Central Nervous System Generation and Modulation of Pain: Early Evidence from Anatomical Brain Imaging and the Development of Functional Brain Imaging p. 73

Anatomical Imaging: Computed Tomography and Magnetic Resonance Imaging p. 73

The Development of Functional Imaging p. 75

Some Essential Background p. 76

The Hemodynamic Response p. 76

Functional Imaging: Functional Magnetic Resonance Imaging and Positron Emission Tomography p. 79

Voxel-Based Morphometry p. 82

10 Functional Imaging Contributions to Chasing Pain p. 83

The Default State of the Brain p. 83

Pain Emerges from the Conjoint Activation of Structures Mediating Sensory, Affective, and Cognitive Functions p. 85

More Caveats: The Salience Network p. 88

The Cognitive Modulation of Pain p. 90

Pain Over Time: Chronic Pain p. 93

Functional Brain Imaging: A Summarizing Comment p. 97

11 Unfinished Business: A Sample p. 98

Headache p. 98

The Limbic System Revisited: A Case Report p. 100

Anesthesia Awareness p. 102

Pain, Consciousness, and Suffering at the Bedside p. 105

Consciousness and the Conceptual Model Revisited p. 105

12 The Chase Today: Summary and Implications p. 110

A Brief Recapitulation p. 110

Peripheral Nervous System p. 112

Central Nervous System p. 113

Implications for Neuroscience p. 115

Implications for Philosophy p. 116.

Notes:

Electronic reproduction. Oxford Available via World Wide Web.

Description based on online resource; title from PDF title page (viewed on March 04, 2019).

Includes index.

Local Notes:

Acquired for the Penn Libraries with assistance from the William Pepper Medical Library Fund.

Other Format:

Print version: CASEY, KENNETH L. CHASING PAIN.

ISBN:

9780190880248

0190880244

9780190920074

0190920076

Publisher Number:

99980647321

Access Restriction:

Restricted for use by site license.