Macrolides : properties, synthesis and applications / Biljana Arsic [and five others].

Format:

Book

Author/Creator:

Arsic, Biljana, author.

Arsic, Biljana, 1980- author.

Language:

English

Subjects (All):

Antibacterial agents.

Macrolide antibiotics.

Physical Description:

1 online resource (112 pages)

Edition:

1st ed.

Place of Publication:

Berlin ; Boston : De Gruyter, [2018]

Language Note:

In English.

Summary:

Macrolide antibiotics represent a class of natural macrocyclic products, one of the most clinically important antibiotics. Unfortunately, the production and development of new macrolide antibiotics are not represented enough in the pharmaceutical industry today. The intention of the book is therefore not only to be a teaching tool for students and experts, but also to draw the attention of the general public to this extremely useful, cheap and relatively unharmful effective anti-macrobials, and potential anti-malarials. The authors introduce the different classes of macrolides and their derivatives, principles of their biological activity, their structure and interactions with biological targets as well as synthetic methods to produce new macrolide antibiotics of similar or improved properties. Special emphasis was put on conjugates of macrolides with nucleobases or nucleosides with numerous applications; among them the most important remains the attempt to overcome bacterial resistance.

Contents:

Frontmatter

Preface

Contents

1. The macrolide antibiotics and their semi-synthetic derivatives / Arsic, Biljana / Barber, Jill / Novak, Predrag

2. The semisynthetic routes towards better macrolide antibiotics / Kragol, Goran

3. Interactions of macrolides with their biological targets / Novak, Predrag

4. Hybrids of macrolides and nucleobases or nucleosides: synthetic strategies and biological results / Sodano, Federica / Rimoli, Maria Grazia

Index

Notes:

Includes bibliographical references and index.

Description based on print version record.

ISBN:

9783110515046

3110515040

9783110515756

311051575X

OCLC:

1025395624