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Epigenetics of chronic pain / edited by Guang Bai, Department of Neural and Pain Sciences, School of Dentistry, and Program in Neuroscience, University of Maryland, Baltimore, MD, United States, Ke Ren, Department of Neural and Pain Sciences, School of Dentistry, and Program in Neuroscience, University of Maryland, Baltimore, MD, United States.
Elsevier ScienceDirect eBook - Biochemistry, Genetics and Molecular Biology 2018 Available online
View online- Format:
- Book
- Series:
- Translational epigenetics series ; Volume 7.
- Translational epigenetics series ; Volume 7
- Language:
- English
- Subjects (All):
- Chronic pain.
- Epigenetics.
- Chronic Pain--genetics.
- Epigenesis, Genetic.
- Epigenomics.
- Medical Subjects:
- Chronic Pain--genetics.
- Epigenesis, Genetic.
- Epigenomics.
- Physical Description:
- 1 online resource (250 pages).
- Edition:
- 1st ed.
- Place of Publication:
- London, England : Academic Press, 2019.
- Summary:
- Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies.The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs.- Compiles all known information on epigenetic regulation of chronic pain in one volume- Covers the basic functionality of epigenetic mechanisms involved in pain management, applications of recent research in understanding different types of chronic pain, and pathways for developing therapeutics- Leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss epigenetics in inflammatory, neuropathic, visceral, and other pain models in-depth- Enables clinicians, researchers, and pharmacologists to better understand and treat chronic pain
- Contents:
- Front Cover
- Epigenetics of Chronic Pain
- Copyright
- Contents
- Contributors
- Preface
- Chapter 1: Epigenetic Tools in Chronic Pain Studies
- Introduction
- Measurement of Molecular Changes
- Sample Preparation
- DNA Methylation/Demethylation
- Genome-wide association studies
- Methylation
- Demethylation
- Gene-specific studies
- Chromatin Remodeling/Histone Modifications
- Global versus genome wide detection
- Gene specific studies of histone modification
- Noncoding RNA
- miRNA assay
- Studies of miRNA functions
- Studies of lncRNAs
- Fourth Epigenetic Mechanism
- Manipulation of Epigenetic Mechanisms
- Pharmacological Tools
- Inhibition of enzymes for DNA methylation/demethylation
- Activator and inhibitor for histone acetylation and deacetylation
- Inhibitor for histone methylation and demethylation
- Genetic Modification of Epigenetic Components
- Classic approaches
- EpiEditors
- Closing Remark
- Acknowledgements
- References
- Chapter 2: Epigenetic Regulation of Peripheral Macrophages in Neuropathic Pain
- Peripheral Sensitization in Neuropathic Pain
- Macrophage Infiltration and Cytokine Production
- Macrophage Polarization in Neuropathic Pain
- Chemokine Systems and Inflammation
- Peripheral Chemokines in Neuropathic Pain
- Epigenetic Regulation of Gene Expression
- Histone Modifications and Chemokine Production
- Epigenetic Regulation of Chemokines and Neuropathic Pain
- Conclusions and Future Directions
- Acknowledgments
- Conflicts of Interest
- Chapter 3: Emphasizing Histone-Related Chromatin Remodeling in the Central Nervous System of Animal Models of Chronic Pain
- Histone-Related Chromatin Remodeling
- Neuropathic Pain Model
- Partial Sciatic Nerve Ligation (PSL) Model (Table 1)
- Spinal Nerve Ligation (SNL) Model (Table 1).
- Chronic Constriction Injury (CCI) Model (Table 2)
- Spared Nerve Injury (SNI) Model (Table 2)
- Chemotherapy-Induced Neuropathic Pain Model (Table 2)
- Inflammatory Pain Model
- CFA-Induced Inflammation Model (Table 3)
- MIA-Induced Inflammation Model (Table 4)
- Other Pain Model
- Opioid-Induced Hyperalgesia Model (Table 5)
- Hindpaw Incision Model (Table 5)
- Conclusions and Perspectives
- Acknowledgment
- Chapter 4: Role of Histone Modifications in Chronic Pain Development
- Histone Methylation
- H3K9me2 and H3K9me3
- H3K27me3
- H3K4me3
- Histone Acetylation
- Histone Variants
- Other Histone-Modifying Factors
- Perspectives
- Chapter 5: Role of DNA Methylation in Chronic Pain
- The Process of DNA Methylation
- DNA Methylation and Neuropathic Pain
- DNA Methylation and Inflammatory Pain
- DNA Methylation and Cancer Pain
- Methyl-CpG-Binding Domain Proteins (MBDs) and Chronic Pain
- DNA Methylation and Clinical Painful Diseases
- Conclusion & Future Perspective
- Chapter 6: Pain-Induced Chromatin Modifications
- Chromatin Modifications for Transcriptional Regulations
- Histone Modifications
- Noncoding RNAs
- DNA Methylation
- Histone Modifications in Chronic Pain
- Noncoding RNAs in Chronic Pain
- DNA Methylation in Chronic Pain
- Conclusion and Future Directions
- Chapter 7: DNA Methylation/Demethylation Homeostasis and Various Pain Conditions
- DNA Methylation and Demethylation
- Emerging Technologies for Studying DNA Methylation and Demethylation
- DNA Methylation/Demethylation and Transcriptional Regulation
- DNA Methylation and Transcriptional Repression
- DNA Demethylation and Transcriptional Activation
- Role of DNA Methylation in Chronic Pain: An Imbalance Between Methylation and Demethylation.
- Mechanisms Underlying the DNA Methylation and Demethylation
- Enhanced Binding Ability of the Demethylated Gene With the Transcription Factor
- Future Treatment Options by Drugging the DNA Methylome
- Concluding Remarks
- Chapter 8: Epigenetic Modulation of Visceral Pain
- Visceral Pain
- Types of Visceral Pain
- Characteristics of Visceral Pain
- Visceral Pain Pathways
- Monitoring Methods of Visceral Pain
- Animal Models of Visceral Pain
- Epigenetic Mechanisms in Visceral Pain
- DNA Methylation in Visceral Pain
- Histone Acetylation in Visceral Pain
- MicroRNA Activities in Visceral Pain
- Conclusion and Future Strategies
- Chapter 9: Noncoding RNAs Are New Players in Chronic Pain
- miRNAs in Chronic Pain
- Long Noncoding RNAs in Chronic Pain
- Circular RNAs in Chronic Pain
- Conclusion
- Chapter 10: Epigenetics of Chronic Visceral Nociception
- Chronic Visceral Pain: A Major Health Care Concern
- Neurobiology of Visceral Nociception
- Modulating Factors of Afferent Input
- Epigenetic Alterations
- Conclusions
- Chapter 11: An Overview of Epigenetic Correlates of Human Chronic Pain Conditions
- Epigenetic Marks and Chronic Pain
- Fibromyalgia and Chronic Widespread Pain
- Role of DNA methylation
- Role of microRNAs
- Headache
- Cancer Pain
- Low Back Pain
- Diabetic Neuropathy
- Chronic Postsurgical Pain
- Neonatal Stress-Related Pain
- Visceral Pain-Irritable Bowel Syndrome (IBS) and miRNA Profiles
- Complex Regional Pain Syndrome and miRNA Profiles
- Sex Differences in miRNA Profiles in Trauma/Stress Pain
- Transient Receptor Potential Cation Channel A1 (TRPA1) and Neuropathic Pain
- Opioid Receptors
- Epigenetics in Painful Disease Conditions.
- Rheumatoid Arthritis
- DNA hypomethylation
- Histone code
- Osteoarthritis
- Endometriosis
- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
- Inflammatory Bowel Diseases and Crohn's Disease
- Periodontal Disease
- Translation and Therapeutic Potential
- General Comments and Concluding Remarks
- Blood-Based Analysis and Brain Epigenetics
- Cell and Tissue-Specificity of Altered Epigenetics
- Implications of Differential Genomic Methylation
- Confounding Factors in Human Epigenetic Studies
- Age
- Sex
- Other factors
- Index
- Back Cover.
- Notes:
- Description based on print version record.
- Description based on publisher supplied metadata and other sources.
- ISBN:
- 0-12-814071-2
- OCLC:
- 1065409653
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