Modern approaches in drug discovery / edited by Charles A. Lesburg.

Format:

Book

Contributor:

Lesburg, Charles A., editor.

Series:

Methods in enzymology ; v. 610.

Methods in enzymology, 0076-6879 ; volume 610

Language:

English

Subjects (All):

Pharmaceutical chemistry.

Drugs--Design.

Drugs.

Physical Description:

xiv, 323 pages : illustrations (some color) ; 24 cm.

Edition:

First edition.

Place of Publication:

Cambridge, MA : Academic Press, an imprint of Elsevier, 2018.

Contents:

Risk Management in Early Discovery Medicinal Chemistry / Gurpreet Singh, Jayme L. Dahlin and Michael A. Walters

Target Identification Using Chemical Probes / Moses Moustakim, Suet Ling Felce, Nancy Zaarour, Gillian Farnie, Fiona E. McCann and Paul E. Brennan

Mining the Microbiome for Drug Targets / Qi Wang, Fangming Yang and Huijue Jia

Screening Library Design / Stephanie Kay Ashenden

Design of a Fragment Screening Library / Ashley Taylor, Bradley C. Doak and Martin J. Scanlon

Genetically Encoded Cyclic Peptide Libraries: From Hit to Lead and Beyond / Jacob Valentine and Ali Tavassoli

A Guide to Run Affinity Screens Using Differential Scanning Fluorimetry and Surface Plasmon Resonance Assays / Christian Bergsdorf and S. Kirk Wright

Second-Harmonic Generation (SHG) for Conformational Measurements: Assay Development, Optimization, and Screening / Tracy A. Young, Ben Moree, Margaret T. Butko, Bason Clancy, Mary Geck Do, Tarun Gheyi, John Strelow, Juan J. Carrillo and Joshua Salafsky

An Array-Based Ligand Discovery Platform for Proteins With Short Half-Lives / Becky S. Leifer, Shelby K. Doyle, André Richters, Helen L. Evans and Angela N. Koehler

High Content, Phenotypic Assays and Screens for Compounds Modulating Cellular Processes in Primary Neurons / Miklos Kepiro, Boglarka H. Varkuti and Ronald L. Davis

Achieving a Good Crystal System for Crystallographic X-Ray Fragment Screening / Patrick M. Collins, Alice Douangamath, Romain Talon, Alexandre Dias, Jose Brandao-Neto, Tobias Krojer and Frank von Delft

Hit-to-Lead: Hit Validation and Assessment / Kirk E. Hevener, Russell Pesavento, JinHong Ren, Hyun Lee, Kiira Ratia, and Michael E. Johnson

Knowledge-Based Approaches to Off-Target Screening / Daniel R. McMasters.

Notes:

Includes bibliographical references.

Other Format:

Online version: Modern Approaches in Drug Discovery.

ISBN:

0128153830

9780128153833

OCLC:

1031458332