Blood-Brain Barrier / edited by Tatiana Barichello.

Format:

Book

Contributor:

Barichello, Tatiana, editor.

SpringerLink (Online service)

Series:

Springer Protocols (Springer-12345)

Neuromethods 0893-2336 ; 142.

Neuromethods, 0893-2336 ; 142

Language:

English

Subjects (All):

Neurosciences.

Local Subjects:

Neurosciences.

Physical Description:

1 online resource (XIII, 367 pages) : 77 illustrations, 54 illustrations in color.

Contained In:

Springer eBooks

Place of Publication:

New York, NY : Springer New York : Imprint: Humana Press, 2019.

System Details:

text file PDF

Summary:

This volume focuses on experimental research with applicable models to study physiology, biochemistry, and molecular biology of the blood-brain barrier (BBB). This book is organized into six parts: Part One is an overview of the physiology of BBB; Part Two explores in vitro cell models to study the BBB; Part Three discusses techniques in vivo and ex vivo models to evaluate BBB in Drosophila melanogaster, Zebrafish, and rodents; Part Four looks at permeability, influx, efflux transportation, and drug delivery through the BBB; Part Five talks about various invasive and non-invasive imaging techniques to study BBB; and Part Six describes how molecular biomarkers are used to look at the integrity or dysfunction of the BBB. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Blood-Brain Barrier is a valuable resource to aid both novice and experienced investigators with performing experiments using new and classic translational approaches.

Contents:

An Overview of the Blood-Brain Barrier

Methods of Delivering Molecules Through the Blood-Brain Barrier for Brain Diagnostics and Therapeutics

Culturing of Rodent Brain Microvascular Endothelial Cells for In Vitro Modelling of the Blood-Brain Barrier

In Vitro BBB Models: Working with Static Platforms and Microfluidic Systems

In Vitro Cell Models of the Human Blood-Brain Barrier: Demonstrating the Beneficial Influence of Shear Stress in Brain Microvascular Endothelial Cell Phenotype

Transepithelial/Transendothelial Electrical Resistance (TEER) to Measure the Integrity of Blood-Brain Barrier

Cell Penetrating Peptides as Theranostics against Impaired Blood-Brain barrier Permeability: Implications for Pathogenesis and Therapeutics Treatment of Neurodegenerative Disease

Microbial Translocation of the Blood-Brain Barrier

Transport across the Choroid Plexus: How to Culture Choroid Plexus Cells and Establish a Functional Assay System

Drosophila as a Model to Study the Blood-Brain Barrier

Zebrafish (Danio rerio) as a Viable Model to Study the Blood-Brain Barrier

Evans Blue-Albumin as a Marker to Evaluate Blood-Brain Barrier Integrity in Neonatal and Adult Rodents

Experimental Tools to Study the Regulation and Function of the Choroid Plexus

Techniques for Evaluating Efflux Transport of Radiolabeled Drugs and Compounds from the Cerebrospinal Fluid acorss the Blood-Cerebrospinal Fluid Barrier

In Vivo Analysis to Study Transport across the Blood-Retinal Barrier

Increasing BBB Permeability via Focused Ultrasound: Current Methods in Pre-Clinical Research

Evaluation of Blood-Brain Barrier Permeability and Integrity in Juvenile Rodents: Dynamic Contrast-Enhanced (DCE), Magnetic Resonance Imaging (MRI), and Evan's Blue Extravasation

Recording Leukocyte Rolling and Adhesion on Meningeal Vessels by Intravital Microscopy

Molecular Imaging of Blood-Brain Barrier Permeability in Preclinical Models Using PET and SPECT

Biomarkers for Microvascular Proteins Detection: Blood-Brain Barrier Injury and Damage Measurement.

Other Format:

Printed edition:

ISBN:

9781493989461

Access Restriction:

Restricted for use by site license.