Neural Circuits Controlling Circadian Rhythms / Anna King.

Format:

Book

Thesis/Dissertation

Author/Creator:

King, Anna, author.

Contributor:

Sehgal, Amita, degree supervisor.

University of Pennsylvania. Cell and Molecular Biology, degree granting institution.

Language:

English

Subjects (All):

Genetics.

Neurosciences.

Cellular biology.

Cell and Molecular Biology--Penn dissertations.

Penn dissertations--Cell and Molecular Biology.

Local Subjects:

Genetics.

Neurosciences.

Cellular biology.

Cell and Molecular Biology--Penn dissertations.

Penn dissertations--Cell and Molecular Biology.

Genre:

Academic theses.

Physical Description:

1 online resource (164 pages)

Contained In:

Dissertation Abstracts International 80-02B(E).

Place of Publication:

[Philadelphia, Pennsylvania] : University of Pennsylvania ; Ann Arbor : ProQuest Dissertations & Theses, 2018.

Language Note:

English

System Details:

Mode of access: World Wide Web.

text file

Summary:

A central question in the circadian biology field is how ∼24-hour oscillations of the molecular clock are translated into overt rhythms of behavior and physiology. Drosophila melanogaster is a powerful system that provided the first understanding of how molecular clocks are generated, and now the neural basis of circadian rhythms. In the Drosophila brain, there are about ∼150 clock neurons that collectively are responsible for timekeeping. This thesis addresses how time-of-day signals are transmitted from the clock neurons to output circuits that drive overt rhythms. This work used a genetic approach to identify genes and circuits that regulate two output rhythms: peripheral transcriptional rhythms and brain-controlled behavioral rhythms. We showed that a specific group of clock neurons, LNds, and neuropeptide F signaling regulate transcriptional rhythms in a peripheral tissue called the fat body. We also built on previous work to map a multisynaptic circuit that regulates behavioral rest:activity rhythms. The rest:activity circuit extends from the central clock neurons, s-LNvs, through multiple neuropeptidergic output neurons to motor centers. The circadian output circuit we have mapped not only receives circadian (time-of-day) signals but also signals that drive the need to sleep. This thesis provides neural bases for the regulation of circadian rhythms and highlights the different and intersecting circuits that ensure behavior and physiology occur at optimal times of day.

Notes:

Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B.

Advisors: Amita Sehgal; Committee members: Greg Bashaw; Marc V. Fuccillo; Thomas A. Jongens; David M. Raizen.

Department: Cell and Molecular Biology.

Ph.D. University of Pennsylvania 2018.

Local Notes:

School code: 0175

ISBN:

9780438427624

Access Restriction:

Restricted for use by site license.