Asymmetric synthesis of non-proteinogenic amino acids / Ashot S. Saghyan and Peter Langer.

Format:

Book

Author/Creator:

Saghyan, Ashot S., author.

Langer, Peter, author.

Language:

English

Subjects (All):

Amino acids--Synthesis.

Amino acids.

Physical Description:

1 online resource (376 p.)

Edition:

1st ed.

Place of Publication:

Weinheim, Germany : Wiley-VCH, 2016.

Summary:

Authored by two internationally recognized experts with an excellent track record, this much-needed reference summarizes latest research in the rapidly developing field of stereoselective synthesis of enantiomerically enriched amino acids, particularly of non-proteinogenic origin. It highlights several different catalytic and stoichiometric asymmetric methods for their synthesis and also provides information on origin, biological properties, different synthetic strategies and important applications in medicine and pharmacology. Essential reading for synthetic chemists working in the field of asymmetric synthesis, natural products and peptide synthesis, stereochemistry, medicinal chemistry, biochemistry, pharmacology, and biotechnology.

Contents:

Cover ; Title Page ; Copyright ; Contents ; List of Abbreviations ; Introduction ; Chapter 1 Non-Proteinogenic -Amino Acids, Natural Origin, Biological Functions; References ; Part I Natural Synthesis of Amino Acids, Mechanisms, and Modeling; References ; Chapter 2 Some Regularities of Mechanisms for the Natural Synthesis of Amino Acids ; References

Chapter 3 Systems for Modeling Some Aspects of Pyridoxal Enzyme Action References ; Chapter 4 Modeling of Processes Associated with Cleavage of C -H and C -C Bonds; References ; Chapter 5 Modeling of , -Elimination Processes of PP-Catalysis, Kinetics, and Stereochemistry; References

Chapter 6 Biomimetic Addition Reaction of Nucleophiles to CoIII Complexes of Dehydroaminobutyric Acid References ; Part II Asymmetric Synthesis of Nonprotein -Amino Acids; Chapter 7 The Main Rules of Asymmetric Synthesis ; References ; Chapter 8 Catalytic Asymmetric Synthesis

8.1 Achiral NiII Complexes of Schiff Bases of Amino Acids 8.1.1 The Alkylation of Achiral NiII Complexes Under Phase-Transfer Catalysis ; 8.1.2 Reactions of 1,4-Michael Addition to Achiral Glycine and Dehydroalanine Complexes ; 8.1.3 Synthesis of Enantiomerically Enriched -Amino Acids

8.1.3.1 The Asymmetric Alkylation of Substrate 65a by Alkyl Halides Under Phase-Transfer Catalysis 8.1.3.2 Asymmetric Aldol Condensation of Achiral NiII Complexes of Amino Acids ; 8.1.3.3 The Asymmetric Michael Addition of Achiral NiII Substrates to Electron-Withdrawing Compounds

8.1.3.4 Catalytic Asymmetric Addition of Nucleophiles to an Achiral Dehydroalanine Substrate

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed August 31, 2016).

ISBN:

9783527804481

352780448X

9783527804474

3527804471

9783527804498

3527804498

OCLC:

956706494