Small molecule medicinal chemistry : strategies and technologies / edited by Werngard Czechtizky, Peter Hamley.

Format:

Book

Contributor:

Czechtizky, Werngard, editor.

Hamley, Peter, editor.

Language:

English

Subjects (All):

Pharmaceutical chemistry.

Drug development.

Physical Description:

1 online resource (655 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, New Jersey : Wiley, 2016.

Language Note:

English

Summary:

Stressing strategic and technological solutions to medicinal chemistry challenges, this book presents methods and practices for optimizing the chemical aspects of drug discovery. Chapters discuss benefits, challenges, case studies, and industry perspectives for improving drug discovery programs with respect to quality and costs. • Focuses on small molecules and their critical role in medicinal chemistry, reviewing chemical and economic advantages, challenges, and trends in the field from industry perspectives • Discusses novel approaches and key topics, like screening collection enhancement, risk sharing, HTS triage, new lead finding approaches, diversity-oriented synthesis, peptidomimetics, natural products, and high throughput medicinal chemistry approaches • Explains how to reduce design-make-test cycle times by integrating medicinal chemistry, physical chemistry, and ADME profiling techniques • Includes descriptive case studies, examples, and applications to illustrate new technologies and provide step-by-step explanations to enable them in a laboratory setting

Contents:

Elements for the development of strategies for compound library enhancement / Edgar Jacoby

The European lead factory / Christopher Kallus, Jörg Hüser, Philip S. Jones, Adam Nelson

Access to compound collections : new business models for compound acquisition and sharing / Peter ten Holte

New advances in diversity-oriented synthesis / Warren R. J. D. Galloway, Jamie E. Stokes, David R. Spring

Solid-phase combinatorial chemistry : ready for a revival? / Marcel Patek, Martin Smrcina, Eric Wegrzyniak, Victor Nikolaev, Andres Mariscal

Recent advances in multicomponent reaction chemistry : applications in small molecule drug discovery / Christopher Hulme, Muhammad Ayaz, Guillermo Martinez-Ariza, Federico Medda, Arthur Shaw

Computational techniques to support hit triage / Douglas B. Kitchen, Hélène Y. Decornez

Fragment-based drug discovery / Jean-Paul Renaud, Thomas Neumann and Luc Van Hijfte

Virtual screening / Karl-Heinz Baringhaus, Gerhard Hessler

Phenotypic screening / Michelle Palmer

Advances in the understanding of drug properties in medicinal chemistry / Peter Hamley, Patrick Jimonet

Recent developments in automated solution phase library production / Thomas C. Maier, Werngard Czechtizky

Adme profiling : an introduction for the medicinal chemist / Katharina Mertsch, Martin Will, Werngard Czechtizky, Niels Griesang, Alexander Marker, Jacob Olsen

The role of natural products in drug discovery : examples of marketed drugs / Lars Ole Haustedt and Karsten Siems

Peptidomimetics of a-helical and b-strand protein binding epitopes / Nina Bionda, Rudi Fasan

In vivo imaging of drug action / Oliver Plettenburg, Matthias Löhn.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

9781118771693

1118771699

9781118771723

1118771729

9781118771570

1118771575

OCLC:

911135112