Vascular responses to pathogens / edited by Felicity N.E. Gavins, Karen Y. Stokes.

Format:

Book

Contributor:

Gavins, Felicity N. E., editor.

Stokes, Karen Y., editor.

Language:

English

Subjects (All):

Pathogenic microorganisms.

Blood-vessels.

Physical Description:

1 online resource (253 p.)

Edition:

1st ed.

Place of Publication:

Amsterdam, [Netherlands] : Academic Press, 2016.

Language Note:

English

Summary:

ascular Responses to Pathogens focuses on the growing research from leaders in the field for both the short and long-term impact of pathogens on the vasculature.It discusses various organisms, including bacteria, parasites, and viruses, and their role in key events leading to vascular disease.Formatted to discuss the topic of the interaction of.

Contents:

""Cover""; ""Title Page""; ""Copyright Page""; ""Contents""; ""List of Contributors""; ""Overview""; ""Chapter 1 - Sepsis""; ""Introduction""; ""The microcirculation in sepsis""; ""The endothelium""; ""Nitric oxide and sepsis""; ""Arterioles""; ""Capillaries""; ""Venules""; ""Permeability""; ""Blood cells""; ""The Inflammatory Response in Sepsis""; ""Platelets in sepsis""; ""Thrombosis and coagulation in sepsis""; ""Models""; ""Genetics and sepsis""; ""Treatments for sepsis""; ""Conclusions""; ""Acknowledgment""; ""References""; ""Chapter 2 - Neutrophil-Mediated Vascular Host Defense""

""Introduction""""Bloodstream infections""; ""Conventional vascular host defense""; ""Neutrophil extracellular trap mediated vascular immunity""; ""Immunothrombosis""; ""NET-mediated tissue damage""; ""Conclusions""; ""References""; ""Chapter 3 - Platelets as Mediators of the Vascular Response to Infection""; ""Introduction""; ""Platelet and hemostasis""; ""Platelets and the response to infection""; ""Platelet-bacteria interactions""; ""Direct binding""; ""Indirect binding""; ""Shear stress""; ""Secreted products""; ""Platelet activation""; ""Platelets and sepsis""; ""Conclusions""

""References""""Chapter 4 - Mechanisms of Bacterial Interaction with Cells of the Blood-Cerebrospinal Fluid Barrier""; ""Introduction""; ""Bacterial meningitis""; ""Neuropathology and Clinical Presentation of Bacterial Meningitis""; ""N. meningitidis""; ""GBS""; ""Blood-brain barrier/blood-cerebrospinal fluid barrier""; ""In Vivo and In Vitro Models to Study the Pathogenesis of Bacterial Meningitis""; ""Bacterial ligand-receptor interactions""; ""Meningococcal Type IV Pili""; ""Meningococcal Opa and Opc Proteins""; ""Other Meningococcal Adhesins and Cortical Plaque Formation""

""GBS Surface Adhesins and Invasins""""GBS Pili and Other ECM-Binding Proteins""; ""Signal-transduction mechanisms""; ""Analysis of the host cell transcriptome in response to bacterial infection""; ""Meningococcal Infection""; ""GBS Infection""; ""Meningococcal Manipulation of the Outer Cell Membrane Lipid Composition""; ""Summary""; ""Acknowledgments""; ""References""; ""Chapter 5 - Vascular Responses to Chlamydia pneumoniae Infection""; ""Introduction""; ""Direct interaction with vascular cells""; ""Receptor-Mediated Binding and Uptake""

""C. pneumoniae Uses the Mannose 6-Phosphate Receptor on Endothelial Cells""""C. pneumoniae Binds to and Activates the LOX-1 Receptor on Endothelial Cells""; ""The C. pneumoniae Developmental Cycle and Persistent Infection""; ""Effects on Host Cell Energy Metabolism""; ""Inflammatory Activation of Vascular Cells and the Role of Toll-Like Receptors""; ""Foam Cell Formation""; ""Effects on Host Cell Turnover""; ""Systemic responses to infection and the impact on the vasculature""; ""Evidence of the Association of C. pneumoniae Infection and Atherosclerosis in Humans""; ""Clinical Trials""

""Animal Models of C. pneumoniae Infection: Effects on Atherosclerosis and Vascular Compliance""

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed November 19, 2015).

Description based on publisher supplied metadata and other sources.

ISBN:

9780128010785

0128010789

9780128013250

0128013257

OCLC:

927969240