The scientist's guide to cardiac metabolism / edited by Michael Schwarzer and Torsten Doenst.

Format:

Book

Contributor:

Schwarzer, Michael, editor.

Doenst, Torsten, editor.

Language:

English

Subjects (All):

Heart--Metabolism.

Heart.

Physical Description:

1 online resource (241 pages)

Edition:

1st ed.

Place of Publication:

Boston : Elsevier, [2016]

Language Note:

English

Summary:

The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism.This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding.

Contents:

Cover; Title Page; Copyright Page; Contents; List of Contributors; Foreword; Chapter 1 - Introduction to Cardiac Metabolism; References; Chapter 2 - Basics in Metabolically Relevant Biochemistry; Carbohydrates; Glycogen as endogenous glucose storage; Lactate; Fatty acids; Ketone bodies; Amino acids - building blocks for proteins; Branched chain amino acids; Cellular uptake of metabolic substrates; Enzyme activities and their regulation; ATP generation through substrate-level phosphorylation and at the proton production level; References

Chapter 3 - Metabolically Relevant Cell Biology - Role of Intracellular Organelles for Cardiac Metabolism; Cellular compartments; Cytosol; Mitochondria: MPTP opening, fusion, fission, mitophagy, and mitobiogenesis; Peroxisomes; Endoplasmic/sarcoplasmic reticulum; Ribosomes and metabolism-regulated protein synthesis; Golgi Apparatus; Transport System and Vesicle Pools; Cell death: necrosis, apoptosis, necroptosis; Apoptosis; Autophagic Cell Death; Necrosis; Necroptosis; References; Chapter 4 - Metabolic Pathways and Cycles; Introduction; Lipids and fatty acids; Fatty acid oxidation

Protein Phosphatases; Pyruvate Dehydrogenase: A Case in Point; Short-Term Control of Enzyme Activity: Other Types of Covalent Modifications; Control of the overall flux through a pathway; Flux Reversal; Flux-Generating Steps; Control by Supply: Push Mechanism; Control by Demand: Pull Mechanism; Substrate Interaction and Competition; Protein-Protein Interactions; Conclusions; References; Chapter 6 - Cardiac Metabolism During Development and Aging; The fetal metabolism is different from maternal metabolism; Fetal Energy Substrates; Fetal Glycolysis; Carbohydrate Oxidation in the Fetal Heart; Spectrophotometric assays of mitochondrial complex activities

Notes:

Description based upon print version of record.

Description based on print version record.

Description based on publisher supplied metadata and other sources.

ISBN:

9780128026144

0128026146

9780128023945

0128023945

OCLC:

936298484