Translating regenerative medicine to the clinic / edited by Jeffrey Laurence, Division of Hematology-Medical Oncology Weill Cornell Medical College and New York Presbyterian Hospital New York, NY, USA [and three others] ; contributors, Graca Almeida-Porada [and eighty-four others].

Format:

Book

Contributor:

Laurence, Jeffrey, editor.

Almeida-Porada, Graca, contributor.

Series:

Advances in translational research.

Advances in Translational Medicine

Language:

English

Subjects (All):

Regenerative medicine.

Clinical medicine.

Physical Description:

1 online resource (356 p.)

Edition:

1st ed.

Place of Publication:

Amsterdam, [Netherlands] : Academic Press, 2016.

Language Note:

English

Summary:

Translating Regenerative Medicine to the Clinic reviews the current methodological tools and experimental approaches used by leading translational researchers, discussing the uses of regenerative medicine for different disease treatment areas, including cardiovascular disease, muscle regeneration, and regeneration of the bone and skin.Pedagogically, the book concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. It promotes cross-disciplinary communication between the sub-specialties of medicine, but remains unified in theme by emphasizing recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole.Volumes in the series include Translating Gene Therapy to the Clinic, Translating Regenerative Medicine to the Clinic, Translating MicroRNAs to the Clinic, Translating Biomarkers to the Clinic, and Translating Epigenetics to the Clinic.- Encompasses the latest innovations and tools being used to develop regenerative medicine in the lab and clinic- Covers the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field- Contains extensive pedagogical updates aiming to improve the education of translational researchers in this field- Provides a transdisciplinary approach that supports cross-fertilization between different sub-specialties of medicine

Contents:

Front Cover; Translating Regenerative Medicine to the Clinic; Copyright; Contents; Contributors; I - Introduction; 1 - Regenerative Medicine: The Hurdles and Hopes; Key Concepts; 1. INTRODUCTION; 2. ON THE ORIGINS OF REGENERATIVE MEDICINE; 3. FROM CELLS AND SCAFFOLDS TO TISSUES AND ORGANS; 4. BIOMATERIALS, TISSUE AND ORGAN BIOENGINEERING; 5. GENE THERAPY; 6. STEM CELL THERAPIES; 7. FUTURE DIRECTIONS; REFERENCES; II - Biomaterials and Tissue/Organ Bioengineering; 2 - Extracellular Matrix as an Inductive Scaffold for Functional Tissue Reconstruction; Key Concepts; 1. INTRODUCTION

5.4 Undesirable Responses to ECM Scaffold Materials6. CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 3 - Whole-Organ Bioengineering-Current Tales of Modern Alchemy; Key Concepts; 1. INTRODUCTION; 2. CURRENT STATUS OF ORGAN TRANSPLANTATION; 3. CURRENT STATUS ON ORGAN BIOENGINEERING; 3.1 Liver; 3.2 Intestine; 3.3 Kidney; 3.4 Heart; 3.5 Pancreas; 3.6 Lungs; 4. CURRENT APPLICATIONS FOR BIOENGINEERED ORGANS; 5. CURRENT LIMITATIONS; 5.1 Cell Sources and Expansion; 5.2 Assembly of Patent Vascular Networks; 5.3 Enabling Bioreactor Technologies; 5.4 Regulatory Challenges, Scaling Up, and Other Issues

6. CONCLUSIONSREFERENCES; 4 - Regenerative Implants for Cardiovascular Tissue Engineering; 1. INTRODUCTION; 1.1 The Path to a Regenerative Approach; 1.2 Brief Historical Overview of Vascular, Heart Valve, and Heart Implants; 1.2.1 Vascular Implants; 1.2.2 Heart Valve; 1.2.3 Whole Heart; 2. TYPES OF REGENERATIVE IMPLANTS-THE CONTINUITY BRIDGE; 2.1 Synthetic; 2.1.1 Degradable Synthetic Polymers; 2.1.2 Fabrication Methods; 2.2 Biologic; 2.2.1 ECM Gels; 2.2.2 Decellularized Scaffolds; 2.2.3 Hybrid; 3. FUNCTION OF IMPLANTS; 3.1 Implants as a Cell Delivery Vehicle Grown In Vitro

3.1.1 Endothelial Progenitor Cells and MSCs3.1.2 Embryonic and Inducible Stem Cells; 3.1.3 BM Cells; 3.1.4 Cell Seeding Techniques; 3.2 Implants as an In Situ "Cell-Free" Tissue Forming Device; 3.3 Implants as a Drug Delivery Vehicle; 4. CLINICAL APPLICATIONS IN CARDIOVASCULAR REPAIR; 4.1 Vascular; 4.1.1 Vascular Patch; 4.1.2 Vascular Grafts; 4.2 Heart Valve; 4.3 Heart; 5. CONCLUSION; ACKNOWLEDGMENT; REFERENCES; 5 - Tissue Engineering and Regenerative Medicine: Gastrointestinal Application; Key Concepts; 1. THE GASTROINTESTINAL TRACT: OVERVIEW; 2. NEURODEGENERATIVE DISEASES OF THE GI TRACT

3. CELL SOURCE IN REGENERATING THE NEUROMUSCULATURE OF THE GI TRACT

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed December 15, 2015).

ISBN:

9780128005521

0128005521

OCLC:

932332263