Chinmedomics : the integration of serum pharmacochemistry and metabolomics to elucidate the scientific value of traditional Chinese medicine / editor, Xijun Wang ; associate editors, Aihua Zhang, Hui Sun.

Format:

Book

Contributor:

Wang, Xijun, editor.

Zhang, Aihua, editor.

Sun, Hui, editor.

Language:

English

Subjects (All):

Pharmaceutical chemistry.

Medicine--China--Philosophy--History.

Medicine.

Medicine, Oriental--Philosophy--History.

Medicine, Oriental.

China.

Physical Description:

1 online resource (408 p.)

Edition:

1st ed.

Place of Publication:

Amsterdam, [Netherlands] : Academic Press, 2015.

Language Note:

English

Summary:

Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM).

Contents:

Cover; Title Page; Copyright Page; Contents; List of Contributors; About the Editor; Preface; Chapter 1 - Origin of Chinmedomics; 1.1 - Introduction; 1.2 - Application and Challenges of TCM; 1.3 - Metabolomics: An Overview; 1.4 - Process of the Serum Pharmacochemistry of TCM; 1.5 - Establishment and Evolution of Chinmedomics; 1.6 - Potential Value of Chinmedomics; 1.7 - Future Perspectives; References; Chapter 2 - Methods and Protocols of Chinmedomics; 2.1 - Introduction; 2.2 - Analytical Technologies; 2.3 - Sampling; 2.4 - Data Extraction and Analysis

2.5 - Marker Identification and Validation2.6 - Correlation Analysis between Marker Metabolites and Absorbed Chemical Components; 2.7 - Goals for Chinmedomics; 2.7.1 - Biological Mechanisms of the TCM Syndrome; 2.7.2 - Pharmacological Effects of Formulae; 2.7.3 - Correlation Analysis of Formulae and Syndrome for Effective Substances; 2.8 - Chinmedomics for Yinchenhao Tang: A Case Study; 2.9 - Conclusions; References; Chapter 3 - Chinmedomics Advancing Drug Discovery and Development from Yinchenhao Tang; 3.1 - Introduction; 3.2 - Experimental Detail; 3.2.1 - Chemicals and Materials

3.3.4 - Cell Test to Verify the Therapeutic Efficacy of the Correlated Chemical Components3.4 - Conclusions; Chapter 4 - Chinmedomics Approach Dissects Therapeutic Properties of ShenQiWan Acting on ShenYangXu Syndrome; 4.1 - Introduction; 4.2 - Experimental Detail; 4.2.1 - Chemicals and Materials; 4.2.2 - Metabolomics Study; 4.2.2.1 - Animal Handling; 4.2.2.2 - Sample Collection and Preparation; 4.2.2.3 - UPLC-Q-TOF-HDMS Analysis; 4.2.2.4 - Metabolic Profiling and Metabolite Analysis; 4.2.3 - Constituents Analysis In Vitro and In Vivo; 4.2.3.1 - Animals

4.2.3.2 - Preparation of SQW Samples for Analysis

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed July 29, 2015).

Description based on publisher supplied metadata and other sources.

ISBN:

9780128031186

0128031182

9780128031179

0128031174

OCLC:

914434569