TRP channels as therapeutic targets : from basic science to clinical use / edited by Arpad Szallasi ; contributors, M. Allen McAlexander [and fifty-nine others].

Format:

Book

Contributor:

Szallasi, Arpad, 1958- editor.

McAlexander, M. Allen, contributor.

Language:

English

Subjects (All):

TRP channels.

Physical Description:

1 online resource (530 p.)

Edition:

1st ed.

Place of Publication:

Amsterdam, [Netherlands] : Academic Press, 2015.

Language Note:

English

Summary:

"TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use" is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings. Contains comprehensive coverage of TRP channels as therapeutic targets, from emerging clinical indications to completed clinical trialsDiscusses TRP channels as validated targets, ranging from obesity and diabetes through cancer and respiratory disorders, kidney diseases, hypertension, neurodegenerative disorders, and moreProvides critical analysis of the complications and side effects that have surfaced during clinical trials, offering evidence-based suggestions for overcoming them

Contents:

Front Cover; TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use; Copyright; Contents; Contributors; Preface; Chapter 1: An Introduction to Transient Receptor Potential Ion Channels and Their Roles in Disease; Discovery and General Properties of TRP Channels; TRP Channels in Normal Physiology; TRP Channels and Sensory Physiology; TRP Channels and Cardiovascular Function; TRP Channels and Gastrointestinal Function; TRP Channels and Urological Function; TRP Channels and the Brain; TRP Channels and Immune Function; TRP Channels and Development; TRP Channels and Disease

Therapeutic Strategies Based on TRP Channel ModulationAcknowledgment; References; Chapter 2: Transient Receptor Potential Dysfunctions in Hereditary Diseases: TRP Channelopathies and Beyond; Introduction; TRPC Channelopathies; TRPV Channelopathies; TRPM Channelopathies; TRPA Channelopathies; TRPML Channelopathies; TRPP Channelopathies; Conclusions; Acknowledgments; References; Chapter 3: The Role of TRPV1 in Acquired Diseases: Therapeutic Potential of TRPV1 Modulators; Introduction; TRPV1 and Pain; TRPV1 and Gastrointestinal System-Related Disease; TRPV1 and Urinary System-Related Diseases

TRPV1 and Central Nervous System-Related DiseasesTRPV1 and Respiratory System-Related Diseases; TRPV1 and Cancer; TRPV1 and Cardiovascular System-Related Diseases; TRPV1 and Metabolic Diseases; TRPV1 and Other Disease Conditions; Conclusions; Acknowledgment; References; Chapter 4: TRP Gene Polymorphism and Disease Risk; TRP Gene Polymorphism; TRPA1 ; The TRPC Subfamily; The TRPM Subfamily; The TRPML Subfamily; The TRPV Subfamily; Disease Risk, Clinical Diagnosis, and Personalized Medicine; References; Chapter 5: Use of Topical Capsaicin for Pain Relief; Introduction; Pharmacodynamics

PharmacokineticsEfficacy and Therapeutic Uses; Postherpetic Neuralgia; HIV -Associated Distal Sensory Polyneuropathy; Other Neuropathic Pain States; Safety and Tolerability; Delivery of Treatment with Capsaicin 8% Patch-Practical Aspects; Application Procedure for the Capsaicin 8% Patch; Postprocedural Instructions for Patients; References; Chapter 6: TRPV1 Agonist Cytotoxicity for Chronic Pain Relief: From Mechanistic Understanding to Clinical Application; Introduction; Mechanisms of TRPV1 Agonist Therapeutic Action; Four Main Determinants of TRPV1 Agonist Actions

Selectivity of RTX at the Cellular LevelRTX Produces a Prolonged Channel Open Time; TRPV1 Is Selectively Expressed in Subpopulations of DRG Neurons; RTX Is Administered Locally; Companion Dog and Human Studies; Companion (Pet) Dog Models of Chronic Pain; TRPV1 Agonists in the Companion Dog Model of Bone Cancer; TRPV1 Agonists in the Companion Dog Model of Osteoarthritis; Human Studies; References; Chapter 7: Intravesical Capsaicin and Resiniferatoxin for Bladder Disorders; Capsaicin and Resiniferatoxin Targets and Effects in the Urinary Bladder

The Rationale for Using Vanilloids to Overcome Lower Urinary Tract Symptoms

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

OCLC:

907610126