Industrial biotechnology : microorganisms / edited by Christoph Wittmann and James C. Liao.

Format:

Book

Contributor:

Whittmann, Christoph, editor.

Liao, James C., editor.

Series:

Advanced biotechnology

Language:

English

Subjects (All):

Microorganisms.

Biotechnology.

Physical Description:

1 online resource (768 pages)

Edition:

1st ed.

Place of Publication:

Weinheim, Germany : Wiley-VCH, [2017]

Summary:

The latest volume in the Advanced Biotechnology series provides an overview of the main production hosts and platform organisms used today as well as promising future cell factories in a two volume book. Alongside describing tools for genetic and metabolic engineering for strain improvement, the authors also impart topical information on computational tools, safety aspects and industrial-scale production. Following an introduction to general concepts, historical developments and future technologies, the text goes on to cover multi-purpose bacterial cell factories, including those organisms that exploit anaerobic biosynthetic power. Further chapters deal with microbes used for the production of high-value natural compounds and those obtained from alternative raw material sources, concluding with eukaryotic workhorses.

Contents:

Cover

Title Page

Copyright

Dedication

Contents

List of Contributors

About the Series Editors

Preface

Volume 1

Part I Industrial Biotechnology: From Pioneers to Visionary

Chapter 1 History of Industrial Biotechnology

1.1 The Beginning of Industrial Microbiology

1.2 Primary Metabolites and Enzymes

1.3 The Antibiotic Era

1.4 The Biotechnology Era Between 1970 and 2015

1.5 How Pioneering Developments Led to Genetic Engineering

References

Chapter 2 Synthetic Biology: An Emerging Approach for Strain Engineering

2.1 Introduction

2.2 Basic Elements

2.3 Functional and Robust Modules

2.4 Microbial Communities

2.5 Conclusions and Future Prospects

Acknowledgments

Chapter 3 Toward Genome-Scale Metabolic Pathway Analysis

3.1 Introduction

3.2 DD Method

3.3 Calculating Short EFMs in Genome-Scale Metabolic Networks

3.4 Conclusions

Chapter 4 Cell-Free Synthetic Systems for Metabolic Engineering and Biosynthetic Pathway Prototyping

4.1 Introduction

4.2 Background

4.3 The Benefits of Cell-Free Systems

4.4 Challenges and Opportunities in Cell-Free Systems

4.5 Recent Advances

4.6 Summary

Part II Multipurpose Bacterial Cell Factories

Chapter 5 Industrial Biotechnology: Escherichia coli as a Host

5.1 Introduction

5.2 E. coli Products

5.3 Rewiring Central Metabolism

5.4 Alternative Carbon Sources

5.5 E. coli Techniques and Concerns

5.6 Conclusions

Chapter 6 Industrial Microorganisms: Corynebacterium glutamicum

6.1 Introduction

6.2 Physiology and Metabolism

6.3 Genetic Manipulation of Corynebacterium glutamicum

6.4 Systems Biology of Corynebacterium glutamicum

6.5 Application in Biotechnology

6.6 Conclusions and Perspectives.

References

Chapter 7 Host Organisms: Bacillus subtilis

7.1 Introduction and Scope

7.2 Identification of Genetic Traits Pertinent to Enhanced Biosynthesis of a Value Product

7.3 Traits to Be Engineered for Enhanced Synthesis and Secretion of Proteinaceous Products

7.4 Engineering of Genetic Traits in Bacillus subtilis

7.5 Genome Reduction

7.6 Significance of Classical Strain Improvement in Times of Synthetic Biology

7.7 Resource-Efficient B. subtilis Fermentation Processes

7.8 Safety of Bacillus subtilis

7.9 Bacillus Production Strains on the Factory Floor: Some Examples

Chapter 8 Host Organism: Pseudomonas putida

8.1 Introduction

8.2 Physiology and Metabolism

8.3 Genetic Manipulation

8.4 Systems Biology

8.5 Application in Biotechnology

8.6 Future Outlook

Part III Exploiting Anaerobic Biosynthetic Power

Chapter 9 Host Organisms: Clostridium acetobutylicum/Clostridium beijerinckii and Related Organisms

9.1 Introduction

9.2 Microorganisms

9.3 Bacteriophages

9.4 ABE Fermentation of Solvent-Producing Clostridium Strains

9.5 Genome-Based Comparison of Solvent-Producing Clostridium Strains

9.6 Regulation of Solvent Formation in C. acetobutylicum

9.7 Genetic Tools for Clostridial Species

9.8 Industrial Application of ABE Fermentation

Chapter 10 Advances in Consolidated Bioprocessing Using Clostridium thermocellum and Thermoanaerobacter saccharolyticum

10.1 Introduction

10.2 CBP Organism Development Strategies

10.3 Plant Cell Wall Solubilization by C. thermocellum

10.4 Bioenergetics of C. thermocellum Cellulose Fermentation

10.5 Metabolic Engineering

10.6 Summary and Future Directions

Chapter 11 Lactic Acid Bacteria

11.1 Introduction.

11.2 Fermented Foods

11.3 Industrially Relevant Compounds

11.4 Conclusions

Conflict of Interest

Volume 2

Part IV Microbial Treasure Chests for High-Value Natural Compounds

Chapter 12 Host Organisms: Myxobacterium

12.1 Introduction into the Myxobacteria

12.2 Phylogeny and Classification

12.3 Physiology

12.4 Growth and Nutritional Requirements

12.5 Genetics and Genomics

12.6 Secondary Metabolism

12.7 Myxococcus

12.8 Sorangium

12.9 Outlook

Chapter 13 Host Organism: Streptomyces

13.1 Introduction

13.2 Streptomyces Genome Manipulation Toolkits

13.3 Hosts for Heterologous Production of Natural Products

Part V Extending the Raw Material Basis for Bioproduction

Chapter 14 Extreme Thermophiles as Metabolic Engineering Platforms: Strategies and Current Perspective

14.1 Introduction

14.2 Bioprocessing Advantages for Extremely Thermophilic Hosts

14.3 Biobased Chemicals and Fuels: Targets and Opportunities

14.4 Considerations for Selecting an Extremely Thermophilic Host

14.5 General Strategies for Genetic Manipulation of Extreme Thermophiles

14.6 Limitations and Barriers to Genetic Modification of Extreme Thermophiles

14.7 Current Status of Metabolic Engineering Efforts and Prospects in Extreme Thermophiles

14.8 Metabolic Engineering of Extreme Thermophiles - Tool Kit Needs

14.9 Conclusions and Future Perspectives

Chapter 15 Cyanobacteria as a Host Organism

15.1 Introduction and Relevance: Cyanobacteria as a Host Organism

15.2 General Description of Cyanobacteria

15.3 Genetic Tools

15.4 Improving Photosynthetic Efficiency

15.5 Direct Conversion of CO2 into Biofuels and Chemicals

15.6 Conclusions

Chapter 16 Host Organisms: Algae.

16.1 Introduction to Algae as an Industrial Organism

16.2 Algal Genetic Engineering

16.3 Therapeutic and Nutraceutical Applications

16.4 Bioenergy Applications

16.5 Other Industrial Applications

16.6 Industrial-Scale Algal Production

16.7 Conclusions and Potential of Algal Platforms

Part VI Eukaryotic Workhorses: Complex Cells Enable Complex Products

Chapter 17 Host Organisms: Mammalian Cells

17.1 Introduction

17.2 Basics of Cellular Structure and Metabolism

17.3 The Genome of CHO Cells

17.4 Molecular Biology Tools

17.5 Kinetics of Growth and Product Formation

17.6 Intracellular Metabolome Analysis

17.7 Proteome and Gene Expression Analysis

17.8 Improving Cellular Performance by Genetic and Metabolic Engineering

17.9 Outlook

Chapter 18 Industrial Microorganisms: Saccharomyces cerevisiae and other Yeasts

18.1 Industrial Application of Yeasts

18.2 Baker's Yeast as Versatile Host for Metabolic Engineering

18.3 Protein Production in Yeasts

18.4 Lipid Production in Yeasts

18.5 Pentose-Utilizing Yeasts

18.6 Conclusions

Chapter 19 Industrial Microorganisms: Pichia pastoris

19.1 Physiology and Genetics of Pichia pastoris

19.2 Methylotrophic Metabolism

19.3 Application for the Production of Recombinant Proteins

19.4 Application of P. pastoris for Metabolite Production

19.5 Conclusion

Index

EULA.

Notes:

Includes index.

Description based on online resource; title from PDF title page (ebrary, viewed December 15, 2016).

ISBN:

9783527807802

3527807802

9783527807796

3527807799

OCLC:

965799612