Handbook of neurobehavioral genetics and phenotyping / edited by Valter Tucci.

Format:

Book

Contributor:

Tucci, Valter, editor.

Language:

English

Subjects (All):

Neurogenetics.

Behavior genetics.

Phenotype.

Physical Description:

1 online resource (843 pages) : illustrations

Edition:

1st ed.

Place of Publication:

Hoboken, New Jersey : Wiley-Blackwell, 2017.

Summary:

The Handbook of Behavioral Genetics and Phenotyping represents an integrative approach to neurobehavioural genetics; worldwide experts in their field will review all chapters. Advanced overviews of neurobehavioural characteristics will add immense value to the investigation of animal mutants and provide unique information about the genetics and behavioural understanding of animal models, under both normal and pathological conditions. Cross-species comparisons of neurobehavioural phenotypes will pave the way for an evolutionary understanding of behaviour. Moreover, while biological sciences are progressing towards a holistic approach to investigate the complexity of organisms (i.e., "systems biology" approach), an integrated analysis of behavioural phenotyping is still lacking. The Handbook of Behavioral Genetics and Phenotyping strengthens the cross-talk within disciplines that investigate the fundamental basis of behaviour and genetics. This will be the first volume in which traditionally distant fields including genomics, behaviour, electrophysiology, neuroeconomics, and computational neuroscience, among others, are evaluated together and simultaneously accounted for during discussions of future perspectives.

Contents:

Intro

Title Page

Copyright

Dedication

Table of Contents

List of Contributors

Preface

Chapter 1: Genetic Screens in Neurodegeneration

Introduction

The Genetics of Neurodegenerative Disorders

Neurodegeneration Disease Models

Genetic Approaches to Discover New Genes Related to Neurodegeneration Using Disease Models

The Future

Acknowledgments

References

Chapter 2: Computational Epigenomics

Background

Profiling and Analyzing the Methylation of Genomic DNA

Profiling and Analyzing Histone Marks

Integration with Other Omics Data

Chromatin States

Unraveling the Cross-talk Between Epigenetic Layers

Chapter 3: Behavioral Phenotyping in Zebrafish: The First Models of Alcohol Induced Abnormalities

Alcohol Related Human Disorders: A Growing Unmet Medical Need

Unraveling Alcohol Related Mechanisms: The Importance of Animal Models

Face Validity: The First Step in Modeling a Human Disorder

Acute Effects of Alcohol in Zebrafish: A Range of Behavioral Responses

Chronic Alcohol Exposure Induced Behavioral Responses in Zebrafish

Effects of Embryonic Alcohol Exposure

Behavioral Phenotyping: Are We There Yet?

Assembling the Behavioral Test Battery

Concluding Remarks

Chapter 4: How does Stress Affect Energy Balance?

Stress

Energy Balance and Metabolic Disorders

How does Stress Affect Energy Balance?

Animal Models of Chronic Stress and their Impact on Energy Balance

Molecular Mechanisms of Stress-Induced Negative and Positive Energy Balance

Conclusion

Chapter 5: Interactions of Experience-Dependent Plasticity and LTP in the Hippocampus During Associative Learning

Introduction: Study of Learning and Memory Processes in Alert Behaving Mammals.

Changes in Synaptic Strength During Learning and Memory

Changes in Synaptic Strength Evoked by Actual Learning can be Modified by Experimentally Evoked Long-term Potentiation

Other Experimental Constraints on the Study of the Physiological Basis of Learning Processes

Functional Relationships Between Experimentally Evoked LTP and Associative Learning Tasks

Future Perspectives

Chapter 6: The Genetics of Cognition in Schizophrenia: Combining Mouse and Human Studies

Genetics of Schizophrenia

Cognitive (dys)functions in Schizophrenia

Translating Cognitive Symptoms in Animal Models

Executive Control

Working Memory

Control of Attention

Chapter 7: The Biological Basis of Economic Choice

Reinforcement Learning in the Brain

Optimal Decisions: Benchmarks for the Analysis of Choice Behavior

Chapter 8: Interval-timing Protocols and Their Relevancy to the Study of Temporal Cognition and Neurobehavioral Genetics

Application of a Timing, Immersive Memory, and Emotional Regulation (Timer) Test Battery

Neural Basis of Interval Timing

What Makes a Mutant Mouse "Tick"?

Proposal of a TIMER Test Battery and Its Application in Reverse Genetics

Behavioral Test Battery Applications in Forward Genetics

Summary

Appendix I

Chapter 9: Toolkits for Cognition: From Core Knowledge to Genes

Core Knowledge: The Domestic Chick as a System Model

A Comparative Perspective on the Genetic and Evolutionary Bases of Social Behavior

Future Directions

Chapter 10: Quantitative Genetics of Behavioral Phenotypes

Human Studies of Quantitative Traits

Mouse Studies of Quantitative Traits.

Use of Mice as Animal Model for Complex Human Traits

Physical Activity - Definitions and Methods of Phenotypic Measurement

Current Results of Quantitative Genetic Basis of PA in Humans

Current Results of Quantitative Genetic Basis of PA in Mice

An Overlap of Genetic Findings Between the Species

Conclusions

Chapter 11: Behavioral Phenotyping in Genetic Mouse Models of Autism Spectrum Disorders: A Translational Outlook

Measuring Social Behavior in ASD Mouse Models

Repetitive Behavior

Behavioral Tests Targeting other ASD Symptoms

Behavioral Phenotyping in ASD Mouse Pups

Future Directions: ASD Mouse Models as a Resource for Gene-environment Interaction Studies

Chapter 12: Genetics of human sleep and sleep disorders

The Mystery of Human Sleep

Extended Wakefulness Induces Sleep

A Unique Activity Pattern Characterizes the Sleeping Brain

Circadian Regulation of Sleep and Associated Disorders

Destabilization of Sleep States and Narcolepsy

Restless Legs Syndrome, A Developmental Sleep Disorder

Unresolved Issues and Future Perspectives

Chapter 13: The Endocannabinoid System in the Control of Behavior

Role of the ECS in Memory Processes

Cannabinoid Regulation of Memory: Neurobiological Mechanisms

Role of the ECS in Fear Processes

Role of the ECS in Feeding Behavior

Chapter 14: Epigenetics in Brain Development and Disease

Epigenetics and Neurodevelopment

Neurodevelopmental Disorders with an Epigenetic Basis

Imprinted Neurodevelopmental Disorders

Trinucleotide Repeat Disorders

Epigenetics of Neurodegenerative Disorders

The Impact of the Environment on the Epigenome

Epigenetic Therapy in Neurodevelopment

Concluding Remarks.

Acknowledgments

Chapter 15: Impact of Postnatal Manipulations on Offspring Development in Rodents

Rodents' Responses to Postnatal Environment and Early Manipulations

Chapter 16: Exploring the Roles of Genetics and the Epigenetic Mechanism DNA Methylation in Honey Bee (Apis Mellifera) Behavior

Genetics of Adult Honey Bee Biology and Behavior

Techniques for Investigating the Genetic Bases of Behavior

DNA Methylation and Honey Bee Behavior

Techniques for Detecting and Assaying DNA Methylation

Techniques for Manipulating DNA Methylation

Concluding Remarks and Future Perspectives

Chapter 17: Genetics and Neuroepigenetics of Sleep

Defining Sleep

Sleep is Genetically Determined

Epigenetics

Neuroepigenetics

Neuroepigenetics of Sleep

Chapter 18: Behavioral Phenotyping Using Optogenetic Technology

Microbial Opsins

Targeting systems

Light Delivery in the Animal Brain

Recording Light-evoked Neuronal Activity

Chapter 19: Phenotyping Sleep: Beyond EEG

Sleep Research

Phenotyping Sleep in Humans

Phenotyping Sleep in Animal Models

Acknowledgements

Chapter 20: A Cognitive Neurogenetics Screening System with a Data-Analysis Toolbox

Mechanisms, Not Procedures

Functional Specificity

No Group Averages

Physiologically Meaningful Measures

Importance of Large-scale Screening and Minimal Handling

Utilizable Archived Data with Intact Data Trails

Chapter 21: Mapping the Connectional Architecture of the Rodent Brain with fMRI

MRI Mapping of Functional Connectivity in the Rodent Brain.

Transgenic Models: Genetic Manipulation of Functional Connectivity Patterns

Chapter 22: Cutting Edge Approaches for the Identification and the Functional Investigation of miRNAs in Brain Science

Identification of Novel MicroRNAs in the Brain

miRNA Expression Analysis in the Brain

Target Identification

miRNA Manipulation/Target Validation

New Frontiers in Small RNA-based Technologies to Cure Nervous System Deficits (Table 22.1)

Conclusion and Perspectives

Are miRNAs Just the "Tip of the Iceberg"? Emerging Classes of Noncoding RNAs and Novel Scenarios

Competing Financial Interests

Index

End User License Agreement.

Notes:

Includes index.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

9781787851023

1787851028

9781118540794

1118540794

9781118540763

111854076X

9781118540770

1118540778

OCLC:

967891788