Neural dynamics of neurological disease / Christopher A. Shaw.

Format:

Book

Author/Creator:

Shaw, Christopher A. (Christopher Ariel), author.

Language:

English

Subjects (All):

Nervous system--Diseases.

Nervous system.

Physical Description:

1 online resource (406 pages, 12 unnumbered pages of plates) : color illustrations, photographs

Edition:

1st ed.

Place of Publication:

Hoboken, New Jersey : Wiley Blackwell, 2017.

Summary:

The emerging understanding of age-related neurological disorders suggests that notions of a single causal gene/toxin being responsible is likely incorrect. Neurological disorders probably arise due to a unique intersection of multiple genetic and toxic factors, combined with additional contributions of age, stage of development, immune system actions, and more. This perspective leads to the view that rather than reflecting only one pathway to end-state disease, each is a spectrum disorder, and every individual case is therefore unique. Neural Dynamics of Neurological Disease argues for a fundamental rethinking of what we think we know about neurological disorders, how they arise and progress, and, crucially, what might be done to "cure" them. It first introduces the concept of neural dynamics of neurological disease, then examines various diseases and gives examples of the interplay of elements such as neural systems, cell types, and biochemical pathways that can contribute to disease. The concluding chapters point the way to how the emerging notion of neurological disease as a dynamic process may lead to more successful treatment options. Providing a cross-disciplinary approach to understanding the origin and progression of neurological disease, Neural Dynamics of Neurological Disease is a timely and valuable resource for neuroscientists, researchers, and clinicians.

Contents:

The dynamics of neurological disease : current views and key issues

Clinical and economic features of age-related neurological diseases

Spectrum of neurological disease, clusters, and ubiquity

Complexity, cascading failures, and neurological diseases

Genetic determinants of neurological disease

Environmental determinants of neurological disease and gene-toxin interactions

The mystery and lessons of ALS-PDC

Neurological disease models and their discontents : validity, replicability, and the decline effect

The progression and the time line of neurological disease

Development, aging, and neurological disease

CNS-immune system interactions and autoimmunity

The impact of synergy of factors in neurological disease

The current status of neurological disease treatments

The future of translational research in neurological disease

Defining the limits for neurological disease treatments

The politics and economics of neurological disease.

Notes:

Includes bibliographical references and index.

Description based on print version record.

ISBN:

9781118634738

111863473X

9781118634479

1118634470

9781118634523

1118634527

OCLC:

962304404