Calcium Entry Channels in Non-Excitable Cells / Juliusz Ashot Kozak.

Format:

Book

Author/Creator:

Kozak, Juliusz Ashot, author.

Contributor:

Putney, James W., Jr.

Series:

Methods in signal transduction.

Methods in Signal Transduction Series

Language:

English

Subjects (All):

Calcium channels--Physiology.

Calcium channels.

Physical Description:

1 online resource (328 pages).

Edition:

First edition.

Place of Publication:

Boca Raton, FL : CRC Press, 2017.

Summary:

Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.--Provided by publisher.

Contents:

chapter 1 Electrophysiological Methods for Recording CRAC and TRPV5/6 Channels

chapter 2 Studies of Structure�Function and Subunit Composition of Orai/STIM Channel

chapter 3 Signaling ER Store Depletion to Plasma Membrane Orai Channels

chapter 4 Modulation of Orai1 and STIM1 by Cellular Factors

chapter 5 CRAC Channels and Ca2+-Dependent Gene Expression

chapter 6 Function of Orai/Stim Proteins Studied in Transgenic Animal Models

chapter 7 Assessing the Molecular Nature of the STIM1/Orai1 Coupling Interface Using FRET Approaches

chapter 8 Optogenetic Approaches to Control Calcium Entry in Non-Excitable Cells

chapter 9 Regulation of Orai/STIM Channels by pH

chapter 10 Non-Orai Partners of STIM Proteins: Role in ER�PM Communication and Ca2+ Signaling

chapter 11 Store-Independent Orai Channels Regulated by STIM

chapter 12 Regulation and Role of Store-Operated Ca2+ Entry in Cellular Profiliferation

chapter 13 TRPV5 and TRPV6 Calcium-Selective Channels

chapter 14 Determining the Crystal Structure of TRPV6

chapter 15 Identifying TRP Channel Subunit Stoichiometry Using Combined Single Channel Single Molecule Determinations (SC-SMD)

chapter 16 Pharmacology of Store-Operated Calcium Entry Channels.

Notes:

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

9781315152592

1315152592

9781498752732

149875273X

9781351648639

1351648632

OCLC:

993686559