Neural control of renal function / Ulla C. Koop.

Format:

Book

Author/Creator:

Kopp, Ulla, author.

Series:

Colloquium digital library of life sciences

Colloquium series on integrated systems physiology ; 2154-5626 # 80.

Colloquium series on integrated systems physiology, 2154-5626 ; # 80

Language:

English

Subjects (All):

Kidneys--Physiology.

Kidneys.

Kidneys--Innervation.

Kidneys--Diseases.

Neurophysiology.

Kidney--innervation.

Medical Subjects:

Kidney--innervation.

Physical Description:

1 online resource (xiii, 105 pages) : illustrations.

Edition:

Second edition.

Place of Publication:

[San Rafael, California] : Morgan & Claypool, 2018.

System Details:

Mode of access: World Wide Web.

System requirements: Adobe Acrobat reader.

text file

Summary:

The kidney is innervated with efferent sympathetic nerve fibers reaching the renal vasculature, the tubules, the juxtaglomerular granular cells, and the renal pelvic wall. The renal sensory nerves are mainly found in the renal pelvic wall. Increases in efferent renal sympathetic nerve activity reduce renal blood flow and urinary sodium excretion by activation of [alpha]1-adrenoceptors and increase renin secretion rate by activation [beta]1-adrenoceptors. In response to normal physiological stimulation, changes in efferent renal sympathetic nerve activity contribute importantly to homeostatic regulation of sodium and water balance. The renal mechanosensory nerves are activated by stretch of the renal pelvic tissue produced by increases in renal pelvic tissue of a magnitude that may occur during increased urine flow rate. Under normal conditions, the renal mechanosensory nerves activated by stretch of the sensory nerves elicits an inhibitory renorenal reflex response consisting of decreases in efferent renal sympathetic nerve activity leading to natriuresis. Increasing efferent sympathetic nerve activity increases afferent renal nerve activity which, in turn, decreases efferent renal sympathetic nerve activity by activation of the renorenal reflexes. Thus, activation of the afferent renal nerves buffers changes in efferent renal sympathetic nerve activity in the overall goal of maintaining sodium balance. In pathological conditions of sodium retention, impairment of the inhibitory renorenal reflexes contributes to an inappropriately increased efferent renal sympathetic nerve activity in the presence of sodium retention. In states of renal disease or injury, there is a shift from inhibitory to excitatory reflexes originating in the kidney. Studies in essential hypertensive patients have shown that renal denervation results in long-term reduction in arterial pressure, suggesting an important role for the efferent and afferent renal nerves in hypertension.

Contents:

Part I. Efferent renal sympathetic nerves

1. Introduction

2. Neuroanatomy

2.1 Neural pathways

2.2 Intrarenal distribution of efferent renal sympathetic nerves

2.3 Characteristics of the efferent renal sympathetic nerve signals

2.4 neurotransmitters

2.5 Adrenoceptors

2.6 Angiotensin II, nitric oxide, and reactive oxygen species

3. Neural control of renal hemodynamics

3.1 Measurements of renal blood flow

3.2 Renal denervation

3.3 Increases in renal sympathetic nerve activity

3.4 Adrenoceptors

4. Neural control of renal tubular function

4.1 Renal denervation

4.2 Increases in renal sympathetic nerve activity

4.2.1 Direct activation of the renal nerves

4.2.2 Reflex-mediated increases and decreases in the activation of the renal nerves

4.3 Adrenoceptors

4.4 Angiotensin

5. Neural control of renin secretion rate

5.1 Increases in efferent renal sympathetic nerve activity

5.2 Interaction between neural and non-neural mechanisms for renin secretion

5.3 Adrenoceptors

Part II. Afferent renal sensory nerves

6. Introduction

7. Neuroanatomy

7.1 Kidney

7.2 Renal sensory receptors

7.3 Projection to the central nervous system

8. Renorenal reflexes

8.1 Activation of afferent renal sensory nerves by physiological stimuli

8.2 Selective afferent renal denervation

8.3 Afferent renal reinnervation

8.4 Interaction between efferent and afferent renal nerve activity

9. Mechanisms involved in the activation of afferent renal sensory nerves

9.1 Substance P

9.2 Mechanisms contributing to the release of substance P from renal pelvic sensory nerves

9.2.1 PGE2

9.2.2 Bradykinin

9.2.3 Angiotensin II

9.2.4 Endothelin

Part III. Pathophysiological states

10. Efferent renal sympathetic and afferent renal nerves

10.1 Hypertension

10.2 Renal failure

10.3 Heart failure

11. Conclusions

References

Author biography.

Notes:

Part of: Colloquium digital library of life sciences.

Includes bibliographical references (pages 77-104).

Title from PDF title page (viewed on August 3, 2018).

Other Format:

Print version:

ISBN:

9781615047765

OCLC:

1047605975

Access Restriction:

Restricted for use by site license.