Animal Models of Movement Disorders : Volume I / edited by Emma L. Lane, Stephen B. Dunnett.

Format:

Book

Contributor:

Lane, Emma L., editor.

Dunnett, S. B. (Stephen B.), editor.

SpringerLink (Online service)

Series:

Neuromethods 0893-2336 ; 61.

Springer Protocols (Springer-12345)

Neuromethods, 0893-2336 ; 61

Language:

English

Subjects (All):

Neurosciences.

Neurology.

Laboratory animals.

Animal Models.

Local Subjects:

Neurosciences.

Neurology.

Animal Models.

Physical Description:

1 online resource (XV, 447 pages) : 74 illustrations, 31 illustrations in color.

Edition:

1.

Contained In:

Springer eBooks

Place of Publication:

Totowa, NJ : Humana Press, 2012.

System Details:

text file PDF

Summary:

Movement is the way that animals interact with their environment and is under the organization and complex control of the brain and spinal cord. Multiple central nervous systems, including cortex, basal ganglia, cerebellum, and brainstem, interact to provide precise motor control and integration. Damage or disease within these systems cause profound motor disturbances in man, which can be effectively modeled in animals to develop a better understanding and treatment of the human condition. Animal Models of Movement Disorders introduces a variety of methods and techniques used to model and assess motor function in experimental animals from lower orders, such as drosophila and c. elegans, through vertebrate species including fish, to mammals, such as rodents and non-human primates. The most advanced contemporary models in each system are presented at multiple levels of analysis from molecular and genetic modeling, lesions, anatomy, neurochemistry, to imaging and behavior. Volume I contains general methods of movement disorder assessment as well as an extensive section on dopamine systems. Comprehensive and meticulous, Animal Models of Movement Disorders serves as a valuable reference for those studying motor disorders by covering methodologies in detail and providing the information necessary to consider both the appropriate models and assessment tools that can most informatively answer the key experimental issues in the field.

Contents:

Why Can't a Rodent Be More like a Man?: A Clinical Perspective

Zebrafish as a Vertebrate Model Organism for Studying Movement Disorders

Methodological Strategies to Evaluate Functional Effectors Related to Parkinson's Disease through Application of C. elegans Models

Effects of Alpha-Synuclein Expression on Behavioral Activity in Drosophila, a Simple Model of Parkinson's Disease

Neurological Evaluation of Movement Disorders in Mice

Rodent Skilled Reaching for Modeling Pathological Conditions of the Human Motor System

High Throughput Mouse Phenotyping

MRI of Neurological Damage in Rats and Mice

Quantification of Brain Function and Neurotransmission System In Vivo by Positron Emission Tomography: A Review of Technical Aspects and Practical Considerations in Preclinical Research

Optical Approaches to Studying the Basal Ganglia

Electrophysiological Analysis of Movement Disorders in Mice

Genetic Models of Parkinson`s Disease

6-OHDA Lesion Models of Parkinson's Disease in the Rat

6-OHDA Toxin Model in Mouse

Rotation in the 6-OHDA Lesioned Rat

Of Rats and Patients: Some Thoughts about Why Rats Turn in Circles and Parkinson's Disease Patients Cannot Move Normally

Comparing Behavioral Assessment of Sensorimotor Function in Rat and Mouse Models of Parkinson's Disease and Stroke

Rodent Models of L-DOPA-Induced Dyskinesia

Using the MPTP Mouse Model to Understand Neuroplasticity: A New Therapeutic Target for Parkinson's Disease?

The MPTP Treated Primate, with Specific Reference to the Use of the Common Marmoset (C. jacchus)

Behavioral Assessment in the African Green Monkey after MPTP Administration.

Other Format:

Printed edition:

ISBN:

9781617792984

Access Restriction:

Restricted for use by site license.