Drug Delivery to the Central Nervous System / edited by Kewal K. Jain.

Format:

Book

Contributor:

Jain, K. K. (Kewal K.), editor.

SpringerLink (Online service)

Series:

Neuromethods 0893-2336 ; 45.

Springer Protocols (Springer-12345)

Neuromethods, 0893-2336 ; 45

Language:

English

Subjects (All):

Neurosciences.

Neurobiology.

Neurochemistry.

Local Subjects:

Neurosciences.

Neurobiology.

Neurochemistry.

Physical Description:

1 online resource (XII, 324 pages) : 98 illustrations, 4 illustrations in color.

Contained In:

Springer eBooks

Place of Publication:

Totowa, NJ : Humana Press, 2010.

System Details:

text file PDF

Summary:

Playing an important role in the treatment of neurological disorders, the delivery of drugs to central nervous system (CNS), both administered directly and administered systematically for targeted action, encounters a major challenge in the form of the blood-brain barrier (BBB), which limits the access of drugs to the brain substance. In Drug Delivery to the Central Nervous System, experts in the field present essential methods used to deliver therapeutics across the BBB, both in experimental animals and in humans. In addition to those methods, several overviews of innovative methods and their applications are presented in order to give a glimpse of the future of this research. As a volume in the successful Neuromethods series, this book presents its protocols with the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Drug Delivery to the Central Nervous System serves as an ideal guide to scientists continuing to pursue knowledge of the delicate interactions between pharmaceuticals and the brain.

Contents:

An Overview of Drug Delivery to the CNS

Receptor-Mediated Transport of Drugs Across the BBB

Disruption of Blood-Brain Barrier by Focused Ultrasound for Targeted Drug Delivery to the Brain

Prediction of Blood-Brain Barrier Penetration by Drugs

Intraparenchymal Delivery and Its Discontents

Intrathecal Drug Delivery by Implanted Pumps

Intracarotid Drug Delivery: Revisiting the Past or Looking into the Future

Vesicular Systems for Intranasal Drug Delivery

Convection-Enhanced Drug Delivery and Monitoring in a Rat Model

Intrathecal Delivery of Stem Cells to the Spinal Cord

CNS Delivery of Peptides Across the BBB Using the Dual-Artery In Situ Brain Perfusion Model

An Engineered Peptide Compound Platform Technology Incorporating Angiopep for Crossing the BBB

Adeno-Associated Virus Mediated Gene Therapy in Ischemic Stroke

Use of Mesenchymal Stem Cells for Gene Delivery to Intracranial Glioma

Convection-Enhanced Drug Delivery to the Brain.

Other Format:

Printed edition:

ISBN:

9781607615293

Access Restriction:

Restricted for use by site license.