Animal Models of Brain Tumors / edited by Ricardo Martínez Murillo, Alfredo Martínez.

Format:

Book

Contributor:

Martínez-Murillo, Ricardo, editor.

Martinez, Alfredo, editor.

SpringerLink (Online service)

Series:

Neuromethods 0893-2336 ; 77.

Springer Protocols (Springer-12345)

Neuromethods, 0893-2336 ; 77

Language:

English

Subjects (All):

Neurosciences.

Neurology.

Laboratory animals.

Animal Models.

Local Subjects:

Neurosciences.

Neurology.

Animal Models.

Physical Description:

1 online resource (XIII, 391 pages) : 66 illustrations, 43 illustrations in color.

Contained In:

Springer eBooks

Place of Publication:

Totowa, NJ : Humana Press : Imprint: Humana Press, 2013.

System Details:

text file PDF

Summary:

Although the available models, whether at the cellular, tissue, or animal level, do not exactly represent the biology of human brain tumors, animal models can offer significant insights into these tumors, providing a better understanding of biological mechanisms underlying tumor generation, growth, angiogenesis, invasion, and metastasis. Animal Models of Brain Tumors brings together developments and discoveries in "in vivo" experimental tumor research that have provided advances in our understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms. Broken into convenient sections, this thorough volume includes topics such as animal model insights into human brain neoplasms, the cellular, molecular, and genetic basis of brain tumors, therapies in the treatment of malignant glioma, as well as imaging technologies in animal tumor models, id est measuring brain tumor growth and metabolism. Written for the popular Neuromethods series, chapters include the kind of detailed description and implementation advice that is essential for achieving successful results. Authoritative and cutting-edge, Animal Models of Brain Tumors provides the key methods needed to validate, compare, and contrast the animal model with its proposed human counterpart and further the understanding of our own serious ailments.

Contents:

Brain Tumor Models to Predict Clinical Outcome: Like the Phoenix?

Animal Models in Cancer Research: Assessment of Severity and the Application of Humane Endpoints

The VM Mouse Model of Glioblastoma Multiforme

Oligodendroglioma Models

Medulloblastoma Model

Learning about Retinoblastoma from Mouse Models that Missed

Ependymoma Models

Meningioma Models

Pituitary Models

Growth Regulation of Nervous System Tumors: Models for Assessment of Angiogenesis in Brain Tumors

Using Genetically-Engineered Mouse Models to Understand Low-Grade Glioma Development and Growth in Children

EGFR and Tumor-Suppressor Function in Brain Cancer Development

Rodent Glioma Models: Intracranial Stereotactic Allografts and Xenografts

Immunotherapy of High-Grade Gliomas: Preclinical In Vivo Experiments in Animal Models

Assessing Mechanisms of Glioblastoma Invasion

Positron Emission Tomography (PET)-Based Molecular Imaging

In Vivo Magnetic Resonance Spectroscopic Imaging (MRSI) and Ex Vivo Quantitative Neuropathology by High Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy (HRMAS)- Single Photon Emission Computed Tomography (SPECT) in Small Animal CNS Research.

Other Format:

Printed edition:

ISBN:

9781627032094

Access Restriction:

Restricted for use by site license.