TRP Channels in Drug Discovery : Volume II / edited by Arpad Szallasi, Tamás Bíró.

Format:

Book

Contributor:

Szállási, Árpád, editor.

Bíró, Tamás, editor.

SpringerLink (Online service)

Series:

Methods in pharmacology and toxicology 1557-2153

Springer Protocols (Springer-12345)

Methods in Pharmacology and Toxicology, 1557-2153

Language:

English

Subjects (All):

Medicine.

Pharmacology.

Proteomics.

Biomedicine.

Pharmacology/Toxicology.

Local Subjects:

Biomedicine.

Pharmacology/Toxicology.

Proteomics.

Physical Description:

1 online resource (XIV, 489 pages) : 78 illustrations, 56 illustrations in color.

Contained In:

Springer eBooks

Place of Publication:

Totowa, NJ : Humana Press : Imprint: Humana Press, 2012.

System Details:

text file PDF

Summary:

Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention. TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field. Volume II presents practical methodologies involving models for disorders of the cardiovascular system, the brain, skin, the metabolic system, as well as colitis, cancer, thermosensation, and musculoskeletal disorders. Written for the Methods in Pharmacology and Toxicology™ series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab. Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.

Contents:

TRPs to Cardiovascular Disease

Anemic Zebrafish Models of Cardiomyopathy

Methods to Study the Effects of TRP Channel Drugs on Vascular Endothelial Cell Function

Atherosclerosis Models with Cell-Mediated Calcification

Models of Hypertension and Blood Pressure Recording

Balloon Injury in Rats as a Model for Studying TRP Channel Contribution to Vascular Smooth Muscle Remodeling

TRP Channels in the Brain

Investigation of the Possible Role of TRP Channels in Schizophrenia

Investigating Diseases of Dopaminergic Neurons and Melanocytes Using Zebrafish

A Practical Guide to Evaluating Anxiety-Related Behavior in Rodents

Rodent Models of Conditioned Fear: Behavioral Measures of Fear and Memory

Chick Anxiety-Depression Screening Model

A Clinically Relevant Thromboembolic Stroke Model in the Aged Rat

Use of Cell-Stretch System to Examine the Characteristics of Mechanosensor Channels: Axonal Growth/Neuroregeneration Studies

Methods in Neuronal Growth Cone Biology

Transient Receptor Potential Channels and Pruritus

Skin Sensitivity Studies

Hair Follicle Culture

Animal Models for Type 1 Diabetes

Type 2 Diabetes Models

Using Diet to Induce Metabolic Disease in Rodents

Rodent Models to Evaluate Anti-Obesity Drugs

Experimental Colitis Models

Tumor Xenograft Models to Study the Role of TRP Channels in Tumorigenesis

Methods to Study Thermonociception in Rodents

Methods for the Assessment of Heat Perception in Humans

Collagen Antibody-Induced Arthritis (CAIA): A Disease-Relevant Model for Studies of Persistent Joint Pain

Animal Models of Muscular Dystrophy.

Other Format:

Printed edition:

ISBN:

9781627030953

Access Restriction:

Restricted for use by site license.