In Vitro Neurotoxicology : Principles and Challenges / edited by Evelyn Tiffany-Castiglioni, Mannfred A. Hollinger.

Format:

Book

Contributor:

Tiffany-Castiglioni, Evelyn, editor.

Hollinger, Mannfred A., editor.

SpringerLink (Online service)

Series:

Methods in pharmacology and toxicology 1557-2153

Springer Protocols (Springer-12345)

Methods in Pharmacology and Toxicology, 1557-2153

Language:

English

Subjects (All):

Medicine.

Pharmacology.

Biomedicine.

Pharmacology/Toxicology.

Local Subjects:

Biomedicine.

Pharmacology/Toxicology.

Physical Description:

1 online resource (XV, 331 pages).

Contained In:

Springer eBooks

Place of Publication:

Totowa, NJ : Humana Press, 2004.

System Details:

text file PDF

Summary:

Neurotoxicity assessment with in vitro systems offers not only a means to better understand mechanisms of action of toxicants and decrease reliance on laboratory animals, but also provides a basis for reliable, high throughput screening of new and untested chemicals. In In Vitro Neurotoxicology: Principles and Challenges, well-respected leaders in the field take a fresh look at their own and others' work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. In thematically organized chapters, the authors employ examples comprised of multiple experimental systems and endpoints, and discuss the use of complementary in vivo/in vitro strategies. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well studied both in vivo and in vitro: lead, mercury, organophosphorus insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. Several neurotoxicology topics covered provide insight into neurodevelopmental and neurodegenerative diseases, including the concept of astroglia as depots for lead and other metals in the central nervous system, the elucidation of factors involved in the onset of puberty in females, and the exploration of endogenous proteins as neurotoxicants. Authoritative and forward-looking, In Vitro Neurotoxicology: Principles and Challenges sets out new concepts and research directions that will facilitate significant improvement in today's methods and systems for in vitro neurotoxicity testing.

Contents:

In Vitro Neurotoxicology

Predictive Value of In Vitro Systems for Neurotoxicity Risk Assessment

Exposure-Dose-Response Paradigm as It Relates to Toxicogenomics

In Vitro Studies of Neurotoxicant Effects on Cellular Homeostasis

Role of Apoptosis in Neurotoxicology

Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants

Cell-Type Specific Responses of the Nervous System to Lead

Effects of Toxicants on Neural Differentiation

Impairment of Synaptic Function by Exposure to Lead

Aggregating Brain Cell Cultures for Neurotoxicological Studies

Use of Complimentary In Vitro and In Vivo Methods for Assessing Neuroendocrine Disruptors

Establishing In Vitro Models to Study Endogenous Neurotoxicants.

Other Format:

Printed edition:

ISBN:

9781592596515

Access Restriction:

Restricted for use by site license.