Molecular Pathology of the Prions / edited by Harry F. Baker.

Format:

Book

Contributor:

Baker, Harry F., editor.

SpringerLink (Online service)

Series:

Methods in molecular medicine 1543-1894 ; 59.

Springer Protocols (Springer-12345)

Methods in Molecular Medicine™, 1543-1894 ; 59

Language:

English

Subjects (All):

Medicine.

Pathology.

Medicine & Public Health.

Local Subjects:

Medicine & Public Health.

Pathology.

Physical Description:

1 online resource (XII, 279 pages).

Contained In:

Springer eBooks

Place of Publication:

Totowa, NJ : Humana Press, 2001.

System Details:

text file PDF

Summary:

It is now widely agreed that the prion protein plays a key role in the molecular pathogenesis of prion diseases-diseases that involve the misfolding of proteins-in both humans and animals. In Molecular Pathology of the Prions, noted prion researcher Harry Baker has asked internationally recognized investigators to review the latest developments in, and novel approaches to, understanding the prion protein and prion diseases at the molecular level. Utilizing a variety of cutting-edge techniques, these distinguished scientists seek to define the normal function of a prion protein, to detect and measure the early immune response to prion disease, and to discover possible therapeutic targets. They also use transgenic mice and new electrophysiological investigations to elucidate the pathogenetic mechanisms involved in prion diseases. Other topics addressed include the neuronal death that occurs in prion disease, the different strains of prion disease agents, and the accumulation of protein deposits within brain parenchyma. State-of-the-art and richly insightful, Molecular Pathology of the Prions captures for basic and clinical neuropathologists the latest developments and approaches to understanding the pathogenesis of prion diseases, including research techniques now likely to enjoy broader application for the more common proteinopathies, such as Alzheimer's and Parkinson's diseases.

Contents:

What Would Thomas Henry Huxley Have Made of Prion Diseases?

Prion Protein as Copper-Binding Protein at the Synapse

A Function for the Prion Protein?

Prion Protein Peptide

Characterization of Bovine Spongiform Encephalopathy and Scrapie Strains/Isolates by Immunochemical Analysis of PrPSc

Differential Targeting of Neurons by Prion Strains

Transgenic Studies of Prion Diseases

Prions: From Neurografts to Neuroinvasion

Cellular and Transgenic Models of Familial Prion Diseases

Central Nervous System Inflammation and Prion Disease Pathogenesis

The Electroneuropathology of Prion Disease

Transmissible Spongiform Encephalopathy Neurobiology and Ultrastructure Suggests Extracellular PrPSc Conversion Consistent with Classical Amyloidosis

Conformation as Therapeutic Target in the Prionoses and Other Neurodegenerative Conditions

Prions of Yeast From Cytoplasmic Genes to Heritable Amyloidosis.

Other Format:

Printed edition:

ISBN:

9781592591343

Access Restriction:

Restricted for use by site license.