Transgenic and Mutant Tools to Model Brain Disorders / edited by Allan V. Kalueff, Carisa L. Bergner.

Format:

Book

Contributor:

Kalueff, Allan V., editor.

Bergner, Carisa L., editor.

SpringerLink (Online service)

Series:

Neuromethods 0893-2336 ; 44.

Springer Protocols (Springer-12345)

Neuromethods, 0893-2336 ; 44

Language:

English

Subjects (All):

Neurosciences.

Neurology.

Laboratory animals.

Animal Models.

Local Subjects:

Neurosciences.

Neurology.

Animal Models.

Physical Description:

1 online resource (XIV, 246 pages) : 17 illustrations.

Contained In:

Springer eBooks

Place of Publication:

Totowa, NJ : Humana Press, 2010.

System Details:

text file PDF

Summary:

As the presence of genetically modified animal models in research laboratories has multiplied, the role of genetic factors in the pathogenesis of brain disorders has become particularly important. The refinement of molecular genetic methods has continued to broaden our understanding of the genetic factors associated with a variety of disorders. In Transgenic and Mutant Tools to Model Brain Disorders, leading scientists specializing in this field contribute a timely collection of recent advances featuring a vast array of topics in order to contribute to the diverse approaches taken toward the evaluation of genetically modified models in biomedical research. Opening with several chapters covering general aspects of genetically modified animal models, the book then continues with detailed chapters on models of specific human brain disorders, including OCD, Rett Syndrome, anxiety disorders, depression, and schizophrenia. As a volume in the successful Neuromethods™ series, the chapters provide authoritative reviews covering the most commonly used approaches in the field. Cutting-edge and concise, Transgenic and Mutant Tools to Model Brain Disorders offers a comprehensive and descriptive overview on a variety of topics in neuroscience and biological psychiatry.

Contents:

General Approaches

Mutant and Transgenic Zebrafish in Modeling Neurobehavioral Disorders

Knockout and Mutant Rats

Rat Mutants with Lateralized Rotational Behavior for Studying Disturbances in Cerebral Asymmetries and Their Involvement in Brain Disorders

GABAA Receptor ?1 Subunit (Gabra1) Knockout Mice: Review and New Results

Basal Ganglia Disorders in Genetic Models and Experimentally Induced Lesions

Estrogen-Deficient Mouse Models in the Study of Brain Injury and Disease

Specific Brain Disorders

The Utility of Genetically Modified Animals in Modeling OCD-Spectrum Disorders

Investigating Rett Syndrome Through Genetic Mouse Models: Presymptomatic, Clearly Symptomatic Phases, and Innovative Therapeutic Approaches

Genetic Animal Models of Anxiety

Genetic Animal Models of Depression

Environmental Enrichment and Gene-Environment Interactions in Mouse Models of Brain Disorders

Mutant and Transgenic Tools in Modeling Schizophrenia.

Other Format:

Printed edition:

ISBN:

9781607614746

Access Restriction:

Restricted for use by site license.