Prion Diseases / edited by Harry F. Baker, Rosalind M. Ridley.

Format:

Book

Contributor:

Baker, Harry F., editor.

Ridley, Rosalind M., editor.

SpringerLink (Online service)

Series:

Methods in molecular medicine 1543-1894 ; 3.

Springer Protocols (Springer-12345)

Methods in Molecular Medicine, 1543-1894 ; 3

Language:

English

Subjects (All):

Life sciences.

Cytology.

Life Sciences.

Cell Biology.

Local Subjects:

Life Sciences.

Cell Biology.

Physical Description:

1 online resource (XV, 319 pages).

Contained In:

Springer eBooks

Place of Publication:

Totowa, NJ : Springer New York, 1996.

System Details:

text file PDF

Summary:

In Prion Diseases leading researchers and clinicians describe their state-of-the-art findings and hypotheses arising from a variety of different approaches to this group of diseases. Their approaches include clinical presentations, epidemiology, transgenic methods, and diagnostic tests via transmission electron microscopy and immunoblotting. The diseases covered include human and animal spongiform encephalopathies, such as Creutzfeldt-Jakob disease, mad cow disease, and scrapie. Prion Diseases illuminates the conflicting hypotheses that have evolved to explain these diverse disorders which can appear as infectious diseases a genetically determined diseases, as well as ones sharing neuropathological similarities with such common neurodegenerative diseases as Alzheimer's disease, Parkinson's disease, and amyotropic lateral sclerosis. It provides a much-needed overview of various approaches to understanding these diseases by showing how researchers have analyzed their different facets, ranging from the epidemiology of the human versions to molecular genetics of the animal forms of the diseases.

Contents:

The Paradox of Prion Disease

Human Spongiform Encephalopathy

Neuropathological Diagnosis of Human Prion Disease

The Diagnosis of Bovine Spongiform Encephalopathy and Scrapie by the Detection of Fibrils and the Abnormal Protein lsoform

Exposure to, and Inactivation of, the Unconventional Agents that Cause Transmissible Degenerative Encephalopathies

Surveillance of Prion Diseases in Humans

Environmental Causes of Human Spongiform Encephalopathy

Bovine Spongiform Encephalopathy

Handling the BSE Epidemic in Great Britain

Special Problems of Genetic Counseling in Adult-Onset Diseases

Genotyping and Susceptibility of Sheep to Scrapie

Strain Typing Studies of Scrapie and BSE

PrP-Deficient Mice in the Study of Transmissible Spongiform Encephalopathies

Transgenic Approaches to Prion "Species-Barrier" Effects

Methods for Studying Prion Protein Amyloid

Methods for Studying Prion Protein (PrP) Metabolism and the Formation of Protease-Resistant PrP in Cell Culture and Cell-Free Systems

Immunohistochemistry of Resinated Tissues for Light and Electron Microscopy.

Other Format:

Printed edition:

ISBN:

9781592595877

Access Restriction:

Restricted for use by site license.