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Targeting Trafficking in Drug Development / edited by Alfredo Ulloa-Aguirre, Ya-Xiong Tao.
Holman Biotech Commons QP905 .H3h v.50 (1978)-v.107 (1993), v.108 pt.2 (1993), v.110 (1994)-v.114 (1995), v.116 (1995)-v.122 (1996) v.124 (1997)-v.133 (1999), v.135 (1999)-v.163:1-2 (2004), v.164 (2004)-v.186 (2008) v.189 (2009),v.192 (2009)-v.195 (2010)v.199 (2010),v.201(2011)-v.217
Available
Levy Dental Medicine Library - Stacks QP905 .H3 v.127
Mixed Availability
- Format:
- Book
- Series:
- Handbook of experimental pharmacology 0171-2004 ; 245.
- Handbook of Experimental Pharmacology, 0171-2004 ; 245
- Language:
- English
- Subjects (All):
- Toxicology.
- Cytology.
- Pharmacology/Toxicology.
- Cell Biology.
- Local Subjects:
- Pharmacology/Toxicology.
- Cell Biology.
- Physical Description:
- 1 online resource (VIII, 425 pages) : 57 illustrations.
- Contained In:
- Springer eBooks
- Place of Publication:
- Cham : Springer International Publishing : Imprint: Springer, 2018.
- System Details:
- text file PDF
- Summary:
- Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.
- Contents:
- 1. Intracellular trafficking of gonadotropin receptors in health and disease
- 2. Investigating internalization and intracellular trafficking of GPCRs
- 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors
- 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases
- 5. Pharmacoperones for misfolded gonadotropin receptors
- 6. Pharmacological chaperones: Beyond conformational disorders
- 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer
- 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches
- 9. Conserved oligomeric Golgi and neuronal vesicular trafficking
- 10. SLC6 transporter folding diseases and pharmacochaperoning
- 11. The molecular physiopathogenesis of islet amyloidosis
- 12. Folding defects leading to primary hyperoxaluria
- 13. Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria. .
- Other Format:
- Printed edition:
- ISBN:
- 9783319741642
- Access Restriction:
- Restricted for use by site license.
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