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Voltage-gated Sodium Channels: Structure, Function and Channelopathies / edited by Mohamed Chahine.
Holman Biotech Commons QP905 .H3h v.50 (1978)-v.107 (1993), v.108 pt.2 (1993), v.110 (1994)-v.114 (1995), v.116 (1995)-v.122 (1996) v.124 (1997)-v.133 (1999), v.135 (1999)-v.163:1-2 (2004), v.164 (2004)-v.186 (2008) v.189 (2009),v.192 (2009)-v.195 (2010)v.199 (2010),v.201(2011)-v.217
Available
Levy Dental Medicine Library - Stacks QP905 .H3 v.127
Mixed Availability
- Format:
- Book
- Series:
- Handbook of experimental pharmacology 0171-2004 ; 246.
- Handbook of Experimental Pharmacology, 0171-2004 ; 246
- Language:
- English
- Subjects (All):
- Toxicology.
- Human genetics.
- Human physiology.
- Biochemistry.
- Pharmacology/Toxicology.
- Human Genetics.
- Human Physiology.
- Protein Structure.
- Local Subjects:
- Pharmacology/Toxicology.
- Human Genetics.
- Human Physiology.
- Protein Structure.
- Physical Description:
- 1 online resource (X, 450 pages) : 80 illustrations, 55 illustrations in color.
- Contained In:
- Springer eBooks
- Place of Publication:
- Cham : Springer International Publishing : Imprint: Springer, 2018.
- System Details:
- text file PDF
- Summary:
- This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.
- Contents:
- Preface
- Part I
- Evolution of voltage-gated sodium channels
- 1. Evolutionary History of Voltage-Gated Sodium Channels
- 2. Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits. - Part II. The structural basis of sodium channel function
- 3. Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective
- 4. The Cardiac Sodium Channel and Its Protein Partners
- 5. : Posttranslational Modification of Sodium Channels
- 6. Sodium Channel Trafficking
- 7. pH Modulation of Voltage-Gated Sodium Channels
- 8. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C
- Part III. Drugs and toxins interactions with sodium channels
- 9. Toxins That Affect Voltage-Gated Sodium Channels
- 10. Mechanisms of Drug Binding to Voltage-Gated Sodium Channels
- 11. Effects of Benzothiazolamines on Voltage-Gated Sodium Channels
- 12. Structural Models of Ligand-Bound Sodium Channels
- 13. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7
- Part IV. Pathophysiology of sodium channels
- 14. Sodium Channelopathies of Skeletal Muscle
- 15. Cardiac Arrhythmias Related to Sodium Channel Dysfunction
- 16. Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain
- 17. Gating Pore Currents in Sodium Channels
- 18. Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells
- 19. Voltage-Gated Sodium Channel b Subunits and Their Related Diseases. .
- Other Format:
- Printed edition:
- ISBN:
- 9783319902845
- Access Restriction:
- Restricted for use by site license.
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