Chemical Mixtures and Combined Chemical and Nonchemical Stressors : Exposure, Toxicity, Analysis, and Risk / edited by Cynthia V. Rider, Jane Ellen Simmons.

Format:

Book

Contributor:

Rider, Cynthia V., editor.

Simmons, Jane Ellen, editor.

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Pharmacology.

Epidemiology.

Environmental health.

Biomedicine.

Pharmacology/Toxicology.

Environmental Health.

Local Subjects:

Biomedicine.

Pharmacology/Toxicology.

Epidemiology.

Environmental Health.

Physical Description:

1 online resource (XIV, 556 pages) : 77 illustrations, 54 illustrations in color

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2018.

System Details:

text file PDF

Summary:

Exposure to multiple chemical and nonchemical stressors is the rule, not the exception. Nevertheless, it continues to be a significant challenge in toxicology and risk assessment to thoroughly take mixtures into account. In this book, both basic and advanced concepts for considering mixtures are discussed, from initial-exposure characterization through the evaluation of risk associated with combined exposures. Several chapters also examine the adoption of promising tools from other disciplines. Looking beyond chemical mixtures, the discussion also addresses incorporating nonchemical stressors into toxicity studies and cumulative-risk assessments. This "excellent" volume-as described by Linda S. Birnbaum, Director of the National Institute of Environmental Health Sciences and the National Toxicology Program, in her foreword to the book-forms "a comprehensive picture of the current state of mixtures science." With contributions from a host of established experts, Chemical Mixtures and Combined Chemical and Nonchemical Stressors: Exposure, Toxicity, Analysis, and Risk is an essential text for mixtures researchers in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics. Both seasoned mixtures researchers and those new to the field will appreciate the clear explanations of mixtures concepts as well as the comprehensive presentation of available tools for predicting mixture effects and estimating risk from combined exposures. This volume also serves as a useful reference book for students. .

Contents:

Introduction

Combined exposures.-Measuring combined exposures

Modeling complex exposures.-Prioritizing mixtures for study

Environment-Wide Association Studies

Biogeographical analysis of chemical co-occurrence

Combining exposure and toxicity information to develop logical groupings for assessment

Maximum Cumulative Ratio for deciding when to assess mixtures

Establishing the "no interaction" baseline

Dose addition models

Response addition

Integrated addition

Mixture statistics - comparing predicted to observed

Cumulative Risk Assessment

Deciding which approach to use

Component-based approaches

Sufficient similarity of whole mixtures

Other whole mixtures approaches

Assessing interactions

Likelihood and examples of chemical interactions

PBPK modeling of chemical interactions

Adding interactions to cumulative risk assessment

Consideration of nonchemical stressors

Toxicity and interactions of physical and chemical stressors

Psychosocial and chemical stressors

Adding nonchemical stressors to cumulative risk assessments

Disease-based risk assessment

Community-based risk assessment.

Other Format:

Printed edition:

ISBN:

9783319562346

Access Restriction:

Restricted for use by site license.