2 options
Developmental Origins of Health and Disease (DOHaD) : From Biological Basis to Clinical Significance / edited by Takeo Kubota, Hideoki Fukuoka.
LIBRA Per. v.1 (1967)-v.111 (1979) v.112 (1980)-v.267 (1990), v.269 (1990)-v.330 (1993), v.332 (1993)-v.363 (1995), v.365 (1994)-v.367 (1995), v.369 (1995)-v.370 (1994), v.371B (1995), v.372 (1995)-v.373 (1995), v.375 (1995)-v.401 (1996), v.403 (1996), v.406 (1997), v.408 (1997)-v.482 (2000)-v.483 (2000)
Available from offsite location
Holman Biotech Commons R850.A1 A39 v.484 (2001)-v.506 Pt.A (2002), v.506 Pt.B (2002), v.507 (2002)-v.538 (2003), v.539 Pt.A-B (2003), v.540 (2003)-v.554 (2004), v.557 (2006)-v.561 (2005), v.563 (2005)-v.585 (2006),v.587 (2006)-v.600 (2007), v.601 (2007)-v.611 v.612-v.664,v.669-v.681,v.682-v.687,v.689-v.694,v.696-v.698,v.700-v.730,v.732-v.740,v.742-v.751,v.754-v.758,v.760,v.762-v.765,v.767-v.771,v.774-v.780,v.782-v.788,v.790,v.942,v.946,v.954,v.961,v.970,v.984-v.986,v.990-v.992
Mixed Availability
- Format:
- Book
- Series:
- Advances in experimental medicine and biology 0065-2598 ; 1012.
- Advances in Experimental Medicine and Biology, 0065-2598 ; 1012
- Language:
- English
- Subjects (All):
- Human physiology.
- Reproductive health.
- Developmental biology.
- Human Physiology.
- Reproductive Medicine.
- Developmental Biology.
- Local Subjects:
- Human Physiology.
- Reproductive Medicine.
- Developmental Biology.
- Physical Description:
- 1 online resource (VII, 95 pages) : 23 illustrations, 16 illustrations in color.
- Contained In:
- Springer eBooks
- Place of Publication:
- Singapore : Springer Singapore : Imprint: Springer, 2018.
- System Details:
- text file PDF
- Summary:
- This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.
- Contents:
- Part 1 Biological Basis
- One carbon metabolism and lipid metabolism in DOHaD
- Novel models of epigenetic gene regulation in the nutritional environment
- Epigenetic switching and neonatal nutritional environment
- Part 2 Disease and environment
- Developmental Origins of Non-Alcoholic Fatty Liver Disease (NAFLD)
- Fetal origins of hypertension
- Involvement of noncoding RNAs in stress-related neuropsychiatric diseases caused by DOCaD theory
- Part 3 Transgenerational mechanism and its consequences
- Placental development and nutritional environment
- Risk of neurodevelopmental disease by paternal aging: a possible influence of epigenetic alteration in sperm
- Part 4 Clinical Significance
- Preemptive epigenetic medicine based on fetal programming.
- Other Format:
- Printed edition:
- ISBN:
- 9789811055263
- Access Restriction:
- Restricted for use by site license.
The Penn Libraries is committed to describing library materials using current, accurate, and responsible language. If you discover outdated or inaccurate language, please fill out this feedback form to report it and suggest alternative language.