Protein-Protein and Domain-Domain Interactions / by Pandjassarame Kangueane, Christina Nilofer.

Format:

Book

Author/Creator:

Kangueane, Pandjassarame, author.

Nilofer, Christina, author.

Contributor:

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Medical genetics.

Vaccines.

Bioinformatics.

Proteins.

Biomedicine.

Gene Function.

Computational Biology/Bioinformatics.

Protein Science.

Vaccine.

Local Subjects:

Biomedicine.

Gene Function.

Computational Biology/Bioinformatics.

Protein Science.

Vaccine.

Physical Description:

1 online resource (XIX, 207 pages) : 161 illustrations, 82 illustrations in color

Contained In:

Springer eBooks

Place of Publication:

Singapore : Springer Singapore : Imprint: Springer, 2018.

System Details:

text file PDF

Summary:

This book illustrates the importance and significance of the molecular (physical and chemical) and evolutionary (gene fusion) principles of protein-protein and domain-domain interactions towards the understanding of cell division, disease mechanism and target definition in drug discovery. It describes the complex issues associated with this phenomenon using cutting edge advancement in Bioinformatics and Bioinformation Discovery. The chapters provide current information pertaining to the types of protein-protein complexes (homodimers, heterodimers, multimer complexes) in context with various specific and sensitive biological functions. The significance of such complex formation in human biology in the light of molecular evolution is also highlighted using several examples. The chapters also describe recent advancements on the molecular principles of protein-protein interaction with reference to evolution towards target identification in drug discovery. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with the molecular interaction of proteins.

Contents:

Module 1. Preface

Module 2. Introduction to protein complexes

Module 3. Historical advancement

Module 4. Databases for protein complexes

Module 5. Types of protein complexes

Module 6. Hetero dimer protein complexes

Module 7. Homo dimer protein complexes

Module 8. Multimer protein complexes

Module 9. Interfaces in protein complexes

Module 10. Principles of protein-protein binding

Module 11. Homodimer folding and binding

Module 12. Gene fusion and protein complexes

Module 13. Domain-domain interactions

Module 14. Protein docking: Methods, software tools and servers

Module 15. Protein complexes, pathways and networks

Module 16. Protein complexes and biological functions

Module 17. Protein complexes in diseases

Module 18. Protein complexes in drug discovery and vaccine development

Module 19. Protein complexes in genome and proteome analysis

Module 20. Conclusions and challenges.

Other Format:

Printed edition:

ISBN:

9789811073472

Access Restriction:

Restricted for use by site license.