G protein-coupled receptors : structure, signaling, and physiology / edited by Sandra Siehler, Graeme Milligan.

Format:

Book

Contributor:

Siehler, Sandra.

Milligan, Graeme.

Language:

English

Subjects (All):

G proteins.

Cell receptors.

Cellular signal transduction.

Receptors, G-Protein-Coupled--physiology.

Signal Transduction--physiology.

Drug Delivery Systems.

Medical Subjects:

Receptors, G-Protein-Coupled--physiology.

Signal Transduction--physiology.

Drug Delivery Systems.

Physical Description:

xvi, 430 pages : illustrations (some color) ; 26 cm

Place of Publication:

Cambridge ; New York : Cambridge University Press, 2011.

Summary:

"This text provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The first chapters of this book illustrate the history of GPCRs based on distinct species and genomic information. This is followed by discussion of the homo- and hetero-oligomerization features of GPCRs, including receptors for glutamate, GABAB, dopamine, and chemokines. Several chapters are devoted to the key signaling features of GPCRs. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically -adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis"--Provided by publisher.

Contents:

Part I. Advances in GPCR Protein Research: 1. The evolution of the repertoire and structure of G protein-coupled receptors / Torsten Schöneberg, Kristin Schröck, Claudia Stäubert and Andreas Russ

2. Functional studies of isolated GPCR-G protein complexes in the membrane bilayer of lipoprotein particles / Adam J. Kuszak, Xiao Jie Yao, Sören G.F. Rasmussen, Brian K. Kobilka and Roger K. Sunahara

Part II. Oligomerization of GPCRs: 3. GPCR-G protein fusions : use in functional dimerization analysis / Graeme Milligan

4. Time-resolved FRET approaches to study GPCR complexes / Jean Phillipe Pin, Damien Maurel, Laetitia Comps-Agrar, Carine Monnier, Marie-Laure Rives, Etienne Doumazane, Philippe Rondard, Thierry Durroux, Laurent Prézeau and Erin Trinquet

5. Signaling of dopamine receptor homo- and hetero-oligomers / Ahmed Hasbi, Brian F. O'Dowd and Susan R. George

6. Functional consequences of chemokine receptor dimerization / Mario Mellado, Carlos Martínez-A., and José Miguel Rodgríguez-Frade

Part III. GPCR Signaling Features: 7. G protein functions identified using genetic mouse models / Stefan Offermanns

8. Kinetics of GPCR, G protein and effector activation / Peter Hein

9. RGS-RhoGEFs and other RGS multidomain proteins as effector molecules in GPCR-dependent and GPCR-independent cell signaling / José Vázquez-Prado and J. Silvio Gutkind

10. Adenylyl cyclase isoform-specific signaling of GPCRs / Karin F.K. Ejendal, Julie A. Przybyla, and Val J. Watts

11. G protein-independent and [beta] arrestin-dependent GPCR signaling / Zhongzhen Nie and Yehia Daaka

12. Assays to read GPCR modulation and signaling / Ralf Heilker and Michael Wolff

Part IV. Ligand Pharmacology of GPCRs: 13. Quantifying allosteric ligand-receptor interactions / Ivan Toma Vranesic and Daniel Hoyer

14. 7TM receptor functional selectivity / Terry Kenakin

Part V. Physiological Functions and Drug Targeting of GPCRs: 15. [Beta]-Adrenoreceptors in cardiovascular and respiratory diseases / Michele Ciccarelli, J. Kurt Chuprun and Walter J. Koch

16. Role of metabotropic glutamate receptors in CNS disorders / Richard M. O'Connor and John F. Cryan

17. S1P receptor agonists, a novel generation of immunosuppressants / Rósa Lopez Almagro, Gema Tarrasón, and Nuria Godessart

18. Wnt/Frizzled receptor signaling in osteoporosis / Georges Rawadi.

Notes:

Includes bibliographical references and index.

ISBN:

9780521112086

0521112087

OCLC:

649795882