Chemical genomics / edited by Haian Fu.

Format:

Book

Contributor:

Fu, Haian.

Language:

English

Subjects (All):

Chemogenomics.

Physical Description:

xi, 345 pages : illustrations (some color) ; 29 cm

Place of Publication:

Cambridge ; New York : Cambridge University Press, 2012.

Summary:

"Advances in chemistry, biology, and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text with contributions from experts in the field discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small-molecule chemicals; the basics of high-throughput screening technologies; and various bioassays for biochemical-, cellular-, and organism-based screens. The final chapters connect the chemical genomics field with personalized medicine and the druggable genome for future discovery of new therapeutics. This book will be valuable to researchers, professionals, and graduate students in many fields, including biology, biomedicine, and chemistry"-- Provided by publisher.

Contents:

Harnessing the power of chemistry for biology and medicine / Cheryl L. Meyerkord and Haian Fu

Exploring biology with small organic molecules / Nicholas Aberle and Craig M. Crews

Chemical proteomics: a global study of protein-small molecule interactions / Akihisa Matsuyama, Yoko Yashiroda, and Minoru Yoshida

Diversity-oriented synthesis / Warren R.J.D. Galloway [and others]

Targeted chemical libraries / Gregory P. Tochtrop and Ryan E. Looper

Fragment-based ligand discovery / Sandra Bartoli, Antonella Squarcia, and Daniela Fattori

Basics and principles for building natural product-based libraries for HTS / Ronald J. Quinn

Essentials for high-throughput screening operations / Stewart P. Rudnicki [and others]

High content analysis and screening: basics, instrumentation, and applications / Paul A. Johnston

Phenotypic screens with model organisms / Grant N. Wheeler, Robert A. Field, and Matthew L. Tomlinson

Screening informatics and cheminformatics / Melinda I. Sosa [and others]

Basics of HTS assay design and optimization / Eduard A. Sergienko

Molecular sensors for transcriptional and post-transcriptional assays / Douglas S. Auld and Natasha Thorne

Time-resolved fluorescence resonance energy transfer technologies in HTS / Yuhong Du and Jonathan J. Havel

Compound profiling with high-content screening methodology / Thomas Mayer and Stephan Schürer

Use of transgenic zebrafish in a phenotypic screen for angiogenesis inhibitors / Jaeki Min [and others]

Flow cytometry multiplexed screening methodologies / Virginia M. Salas [and others]

Label-free biosensor technologies in small molecule modulator discovery / Yuhong Du [and others]

Basic principles and practices of computer-aided drug design / Chao-Yie Yang, Denzil Bernard, and Shaomeng Wang

Computational approach for drug target identification / Honglin Li [and others]

Pharmacogenomics to link genetic background with therapeutic efficacy and safety / Mark M. Bouzyk, Weining Tang, and Brian Leyland-Jones

Drugs, genomic response signatures, and customized cancer therapy / Rafael Rosell, Teresa Moran, and Miguel Taron

Current drug targets and the druggable genome / Margaret A. Johns, Andreas Russ, and Haian Fu.

Notes:

Includes bibliographical references and index.

ISBN:

9780521889483

0521889480

OCLC:

729574114