Pharmaceutics / Shelley Chambers Fox.

Format:

Book

Author/Creator:

Fox, Shelley Chambers, author.

Series:

Remington education.

Remington education

Language:

English

Subjects (All):

Drugs--Dosage forms.

Drugs.

Drugs--Handbooks, manuals, etc.

Pharmacology--Handbooks, manuals, etc.

Pharmacology.

Pharmacy--Practice--Handbooks, manuals, etc.

Pharmacy.

Physical Description:

1 online resource (561 p.)

Edition:

1st ed.

Place of Publication:

London : University of Sciences Philadelphia College of Pharmacy : Pharmaceutical Press, [2014]

Language Note:

English

Summary:

Comprehensive yet concise coverage of all aspects of pharmaceutics. The first part of the book covers physico-chemical principles and highlights the importance of designing dosage forms that contain the appropriate dose, are stable, palatable, easily used by the patient and release drugs in a predictable fashion for absorption. The second part applies these formulation principles to the design of dosage forms used by each route of administration. Each chapter advises on both the science of the delivery mechanism and appropriate use of that delivery system including patient counselling points.

Contents:

Cover; Half Title; Remington Education; Title Page; Copyright; Table of Contents; Preface; About the author; Acknowledgments; 1 Introduction to dosage form design; Introduction; Properties of the drug; Qualities of the ideal dosage form; Pharmaceutical necessities; Properties of the routes of administration; Routes of administration; Liberation, absorption, distribution, metabolism and elimination (LADME); Selected reading; 2 Intermolecular forces and the physical and pharmaceutical properties of drugs; Introduction

Solid state, forces between ions and molecules, and physical properties of drugsSurface interactions and the pharmaceutical properties of drugs; Solubility and dissolution; Partitioning behavior of drug molecules: Log P; Dissolution of solids; Selected reading; 3 Dispersed systems; Introduction; Behavior of molecular solutions, colloidal dispersions, and coarse dispersions; Flow and viscosity; Questions and cases; Selected reading; 4 Properties of solutions and manipulation of solubility; Introduction; Colligative properties of molecular solutions; Manipulation of solubility; Selected reading

5 Chemical stability of drugsIntroduction; Common pathways of drug degradation; Small drug molecules; Oxidation; Photolysis; Racemization; Protein drug degradation; Rates of drug degradation reactions; Managing chemical stability problems; Selected reading; 6 Drug travel from dosage form to receptor; Introduction; Physicochemical factors; Water solubility; Log P; Log D; pH/pKa; Molecular weight; Biological factors; Membrane structure and transport mechanisms; Movement of drugs across membranes; Blood flow, tissue perfusion, and other modes of distribution; Tissue and plasma protein binding

Drug metabolism (Table 6.5)Dosage form factors; Patient factors; Selected reading; 7 Bioavailability, bioequivalence and the Biopharmaceutical Classification System; Introduction; Pharmaceutical equivalence + bioequivalence = therapeutic equivalence; Bioavailability; Bioequivalence of systemically available drug products; Biopharmaceutical Classification System; Biopharmaceutical Drug Disposition Classification System; Selected reading; 8 Parenteral drug delivery; Introduction; Characteristics of parenteral administration routes; Parenteral dosage forms

Preparation and handling of parenteral productsParenteral stability/compatibility; Patient counseling; Selected reading; 9 Delivery of biopharmaceuticals and the use of novel carrier systems; Introduction; Physicochemical and biological properties; Movement from administration site to target; Design of delivery systems; Biosimilars; Selected reading; 10 Drug delivery to the eye; Introduction; Characteristics of the ophthalmic route; Drug properties and the eye; Dosage forms for the ophthalmic route (Table 10.3); Counseling patients; Ophthalmic ointment and gels; Selected reading

11 Drug delivery to and from the oral cavity

Notes:

"University of the Sciences, Philadelphia College of Pharmacy."

Includes bibliographical references and index.

Description based on print version record.

ISBN:

0-85711-158-2

OCLC:

890575593