Childhood leukemias / edited by Ching-Hon Pui.

Format:

Book

Contributor:

Pui, Ching-Hon, 1951- editor.

Series:

Cambridge medicine (Series)

Cambridge medicine

Language:

English

Subjects (All):

Leukemia in children.

Physical Description:

1 online resource (xi, 880 pages) : digital, PDF file(s).

Edition:

Third edition.

Place of Publication:

Cambridge : Cambridge University Press, 2012.

Language Note:

English

Summary:

New insights into the molecular biology of childhood leukemias have stimulated numerous advances in diagnostic methods, strategies for risk assessment and the development of novel therapy for genetic subtypes of the diseases. Fully revised and updated, this new edition of Childhood Leukemias provides the most comprehensive, clinically-oriented and authoritative reference dedicated to these diseases. Beginning with an overview of history, cell biology, and pathology, subsequent chapters review approaches in the evaluation and management of specific leukemias, new therapeutic development and the unique pharmacodynamics and pharmacogenetics of individual patients. New chapters include epigenetics of leukemias, leukemias in patients with Down syndrome and leukemia in adolescents and young adults. The final section covers the complications associated with the disease or its treatment and supportive care during and after treatment. Authored by leading experts, this is a 'must-have' for any physician or investigator who deals with leukemias in childhood.

Contents:

Section I. History and General Issues: History of leukemia: historical perspectives / Paul S. Gaynon, Toska J. Zomorodian and Donald Pinkel

Diagnosis and classification / Mihaela Onciu and Ching-Hon Pui

Epidemiology and etiology / Logan G. Spector, Bridget Charbonneau and Leslie L. Robison

Section II. Cell Biology and Pathobiology: Immunophenotyping / Frederick G. Behm

Immunoglobulin and T-cell receptor gene rearrangements / Jacques J.M. van Dongen and Anton W. Langerak

Cytogenetics of acute leukemias / Susana C. Raimondi

Molecular genetics of acute lymphoblastic leukemias / Charles G. Mullighan

Molecular genetics of acute myeloid leukemia / Tanja A. Gruber and James R. Downing

Epigenetics of leukemia / William Stevenson and Guillermo Garcia-Manero

Genetics and cellular drug resistance in acute leukemia / Monique L. den Boer and Rob Pieters

Heritable predispositions to childhood hematologic malignancies / Alix E. Seif, Beverly J. Lange, Jaclyn A. Biegel, and Kim E. Nichols

Section III. Evaluation and Treatment:- Pharmacokinetic, pharmacodynamic, and pharmacogenetic considerations / Stephen W. Paugh, Mary V. Relling and Williams E. Evans

Acute lymphoblastic leukemia / Ching-Hon Pui

Relapsed acute lymphoblastic leukemia / Günter Henze and Arend von Stackelberg

B-cell acute lymphoblastic leukemia and Burkitt lymphoma / John T. Sandlund and Mihaela Onciu

Acute myeloid leukemia / Jeffrey E. Rubnitz, Hiroto Inaba and Raul C. Ribeiro.

Relapsed acute myeloid leukemia / Ursula Creutzig

Myelodysplastic syndrome / Henrik Hasle

Chronic myeloproliferative disorders / Charlotte M. Niemeyer and Franco Locatelli

Leukemias in patients with Down syndrome / Jeffrey W. Taub, April Sorrell and James A. Whitlock

Treatment of adolescents and young adults with acute lymphoblastic leukemia / James Nachman

Hematopoietic stem cell and natural killer cell transplantation / Wing Leung and Michael A. Pulsipher

Treatment of acute leukemia in countries with limited resources / Raul C. Ribeiro, Scott C. Howard and Ching-Hon Pui

Antibody-targeted therapy / Alan S. Wayne

Adoptive cellular immunotherapy / Hyoung Jin Kang, Cliona M. Rooney and Helen E. Heslop

Gene transfer: methods and applications / Ulrike Gerdemann, Martin Pule and Malcolm K. Brenner

Development therapeutics / Sima Jeha

Minimal residual disease / Dario Campana, Andrea Biondi and Jacques J.M. van Dongen

Section IV. Complications and Supportive Care: Acute complications / Scott C. Howard, Raul C. Ribeiro and Ching-Hon Pui

Late complications after leukemia therapy / Melissa M. Hudson

Therapy-related leukemias / Carolyn A. Felix

Infectious complications in leukemia / Hana Hakim and Patricia M. Flynn

Hematologic supportive care / Fariba Navid and Victor M. Santana

Pain management / Doralina L. Anghelescu and Roland Kaddoum

Psychosocial issues / Sean Phipps, Vida L. Tyc, Heather Conklin and Kevin Krull

Nursing care / Jami S. Gattuso, Martha May and Michele Chandler.

Notes:

Title from publisher's bibliographic system (viewed on 05 Oct 2015).

Includes bibliographical references and index.

ISBN:

1-107-22356-3

1-139-50776-1

0-511-97763-8

1-280-77383-9

9786613684608

1-139-51730-9

1-139-51473-3

1-139-51380-X

1-139-51638-8

1-139-51823-2

OCLC:

796383837