Lysosomes : biology, diseases, and therapeutics / edited by Frederick R. Maxfield, James M. Willard, Shuyan Lu.

Format:

Book

Contributor:

Maxfield, Frederick R., editor.

Willard, James M., 1955- editor.

Lu, Shuyan, 1971- editor.

Standardized Title:

Lysosomes (Maxfield)

Language:

English

Subjects (All):

Lysosomes.

Physical Description:

1 online resource (562 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, New Jersey : Wiley, 2016.

Language Note:

English

Summary:

Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development. • Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates • Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair • Introduces new pathways in therapeutic development and new mechanisms in drug development

Contents:

Lysosomes an introduction / Frederick R. Maxfield

Lysosome biogenesis and autophagy / Fulvio Reggiori, Judith Klumperman

Multivesicular bodies: roles in intracellular and intercellular signalling / Emily R. Eden, Thomas Burgoyne, Clare E. Futter

Lysosomes and mitophagy / Dominik Haddad, Patrik Verstreken

Lysosome exocytosis and membrane repair / Rajesh K. Singh, Abigail S. Haka

Role of lysosomes in lipid metabolism / Frederick R. Maxfield

TFEB, master regulator of cellular clearance / Graciana Diez-Roux and Andrea Ballabio

Lysosomal membrane permeabilization in cell death / Urska Repnik, Boris Turk

The lysosome in aging-related neurodegenerative diseases / Ralph A. Nixon

Lysosome and cancer / Marja Jaattela and Tuula Kallunki

The genetics of sphingolipid hydrolases & sphingolipid storage diseases / Edward H. Schuchman and Calogera M. Simonaro

Lysosome-related organelles : modifications of the lysosome paradigm / Adriana R. Mantegazza and Michael S. Marks

Autophagy inhibition as a strategy for cancer therapy / Xiaohong Ma, Shengfu Piao, Quentin Mcafee, and Ravi K. Amaravadi

Autophagy enhancers, are we there yet? / Shuyan Lu & Ralph A Nixon

Pharmacological chaperones as potential therapeutics for lysosomal storage disorders: preclinical research to clinical studies / Robert E. Boyd, Elfrida R. Benjamin, Su Xu, Richie Khanna, and Kenneth J. Valenzano

Endosomal escape pathways for delivery of biologics / Philip L. Leopold

Lysosomes and antibody drug conjugates / Michelle Mack, Jennifer Kahler, Boris Shor, Michael Ritchie, Maureen Dougher, Matthew Sung, and Puja Sapra

The mechanisms and therapeutic consequences of amine-containing drug sequestration in lysosomes / Nadia Hamid and Jeffrey P. Krise

Lysosome dysfunction : an emerging mechanism of xenobiotic-induced toxicity / Shuyan Lu, Bart Jessen, Yvonne Will & Greg Stevens

Lysosomes and phospholipidosis in drug development and regulation / James M. Willard and Albert De Felice.

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

9781118978313

1118978315

9781118978306

1118978307

9781118978320

1118978323

OCLC:

940796151