Industrial biotechnology : products and processes / edited by Christoph Wittmann and James C. Liao.

Format:

Book

Contributor:

Wittmann, Christoph, editor.

Liao, James C., editor.

Series:

Advanced biotechnology ; v. 4.

Advanced Biotechnology ; Volume 4

Language:

German

Subjects (All):

Biotechnology industries.

Physical Description:

1 online resource (642 pages) : color illustrations.

Edition:

1st ed.

Place of Publication:

Weinheim, Germany : Wiley-VCH, 2017.

Summary:

The latest volume in the Advanced Biotechnology series provides an overview of the main product classes and platform chemicals produced by biotechnological processes today, with applications in the food, healthcare and fine chemical industries. Alongside the production of drugs and flavors as well as amino acids, bio-based monomers and polymers and biofuels, basic insights are also given as to the biotechnological processes yielding such products and how large-scale production may be enabled and improved. Of interest to biotechnologists, bio and chemical engineers, as well as those working in the biotechnological, chemical, and food industries.

Contents:

Cover

Title Page

Copyright

Dedication

Contents

List of Contributors

About the Series Editors

Preface

Part I Enabling and Improving Large-Scale Bio-production

Chapter 1 Industrial-Scale Fermentation

1.1 Introduction

1.2 Industrial-Scale Fermentation Today

1.3 Engineering and Design Aspects

1.4 Industrial Design Examples

1.5 Cost Analysis for the Manufacture of Biotechnological Products

1.6 Influence of Process- and Facility-Related Aspects on Cost Structure

Acknowledgments

References

Chapter 2 Scale-Down: Simulating Large-Scale Cultures in the Laboratory

2.1 Introduction

2.2 Heterogeneities at Large Scale and the Need for Scaling Down

2.3 Bioreactor Scale-Down

2.4 Tools to Study Cell Responses to Environmental Heterogeneities

2.5 Physiological Effects of Environmental Heterogeneities

2.6 Improvements Based on Scale-Down Studies: Bioreactor Design and Cell Engineering

2.7 Perspectives

Acknowledgment

Chapter 3 Bioreactor Modeling

3.1 Large-Scale Industrial Fermentations: Challenges for Bioreactor Modeling

3.2 Bioreactors

3.3 Compartment and Hybrid Multizonal/Computational Fluid Dynamics Approaches for the Description of Large-Scale Bioreactor Phenomena

3.4 Computational Fluid Dynamics Modeling: Unstructured Continuum Approach (Euler-Euler)

3.5 Computational Fluid Dynamics Modeling: Structured Segregated Approach (Euler-Lagrange)

3.6 Conclusion

3.7 Outlook

Chapter 4 Cell Culture Technology

4.1 Introduction

4.2 Overview of Applications for Cell Culture Products and Tissue Engineering

4.3 Fundamentals

4.4 Bioreactors for Cell Culture

4.5 Downstream

4.6 Regulatory and Safety Issues

4.7 Conclusions and Outlook

Part II Getting Out More: Strategies for Enhanced Bioprocessing.

Chapter 5 Production of Fuels and Chemicals from Biomass by Integrated Bioprocesses

5.1 Introduction

5.2 Utilization of Starchy Biomass

5.3 Utilization of Lignocellulosic Biomass

5.4 Conclusions and Perspectives

Chapter 6 Solid-State Fermentation

6.1 Introduction

6.2 Fundamentals Aspects of SSF

6.3 Factors Affecting Solid-State Fermentation

6.4 Scale-Up

6.5 Product Recovery

6.6 Bioreactor Designing

6.7 Kinetics and Modeling

6.8 Applications

6.9 Challenges in SSF

6.10 Summary

Chapter 7 Cell Immobilization: Fundamentals, Technologies, and Applications

7.1 Introduction

7.2 Fundamentals of Cell Immobilization

7.3 Immobilization with Support Materials

7.4 Self-Immobilization

7.5 Immobilized Cells and their Applications

7.6 Bioreactors for Cell Immobilization

7.7 Challenges and Recommendations for Future Research

7.8 Conclusions

Part III Molecules for Human Use: High-Value Drugs, Flavors, and Nutraceuticals

Chapter 8 Anticancer Drugs

8.1 Natural Products as Anticancer Drugs

8.2 Anticancer Drug Production

8.3 Important Anticancer Natural Products

8.4 Prospects

Chapter 9 Biotechnological Production of Flavors

9.1 History

9.2 Survey on Today's Industry

9.3 Regulations

9.4 Flavor Production

9.5 Biotechnological Production of Flavors

9.6 Vanillin

9.7 2-Phenylethanol

9.8 Benzaldehyde

9.9 Lactones

9.10 Raspberry Ketone

9.11 Green Notes

9.12 Nootkatone

9.13 Future Perspectives

Chapter 10 Nutraceuticals (Vitamin C, Carotenoids, Resveratrol)

10.1 Introduction

10.2 Vitamin C

10.3 Carotenoids

10.4 Resveratrol

10.5 Future Perspectives

Part IV Industrial Amino Acids.

Chapter 11 Glutamic Acid Fermentation: Discovery of Glutamic Acid-Producing Microorganisms, Analysis of the Production Mechanism, Metabolic Engineering, and Industrial Production Process

11.1 Introduction

11.2 Discovery of the Glutamic Acid-Producing Bacterium C. glutamicum

11.3 Analysis of the Mechanism of Glutamic Acid Production by C. glutamicum

11.4 Metabolic Engineering of C. glutamicum for Glutamic Acid Production

11.5 Glutamic Acid Fermentation by Other Microorganisms

11.6 Industrial Process of Glutamic Acid Production

11.7 Future Perspectives

Chapter 12 l-Lysine

12.1 Uses of l-Lysine

12.2 Biosynthesis and Production of l-Lysine

12.3 The Chassis Concept: Biotin Prototrophy and Genome Reduction

12.4 l-Lysine Biosensors for Strain Selection and on-Demand Flux Control

12.5 Perspective

Part V Bio-Based Monomers and Polymers

Chapter 13 Diamines for Bio-Based Materials

13.1 Introduction

13.2 Diamine Metabolism in Bacteria

13.3 Putrescine - 1,4-Diaminobutane

13.4 Cadaverine - 1,5-Diaminopentane

13.5 Conclusions and Perspectives

Chapter 14 Microbial Production of 3-Hydroxypropionic Acid

14.1 Introduction

14.2 3-HP Obtained from Native Producers

14.3 Synthesis of 3-HP from Glucose

14.4 Synthesis of 3-HP from Glycerol

14.5 Bridging the Gap Between Glucose and Glycerol in 3-HP Production

14.6 Other Strains for 3-HP Production from Glycerol

14.7 Limitations of 3-HP Synthesis

14.8 Conclusions and Future Prospects

Chapter 15 Itaconic Acid - An Emerging Building Block

15.1 Background, History, and Economy

15.2 Biosynthesis of Itaconic Acid

15.3 Production Conditions for Itaconic Acid

15.4 Physiological Effects and Metabolism of Itaconic acid.

15.5 Metabolic Engineering for Itaconic Acid Production

15.6 Outlook

Part VI Top-Value Platform Chemicals

Chapter 16 Microbial Production of Isoprene: Opportunities and Challenges

16.1 Introduction

16.2 The Milestones of Isoprene Production

16.3 Microbial Production of Isoprene: Out of the Laboratory

16.4 Main Challenges for Bioisoprene Production

16.5 Future Prospects

Chapter 17 Succinic Acid

17.1 Introduction

17.2 Development of Succinic Acid Producers and Fermentation Strategies

17.3 Succinic Acid Recovery and Purification

17.4 Summary

Part VII Biorenewable Fuels

Chapter 18 Ethanol: A Model Biorenewable Fuel

18.1 Introduction

18.2 Metabolic Engineering: Design, Build, Test, Learn

18.3 Biomass Deconstruction

18.4 Closing Remarks

Chapter 19 Microbial Production of Butanols

19.1 Introduction

19.2 A Historical Perspective of n-Butanol Production

19.3 ABE Fermentation

19.4 n-Butanol Production in Non-native Producers

19.5 Isobutanol Production

19.6 Summary and Outlook

Index

EULA.

Notes:

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed December 9, 2016).

ISBN:

9783527807840

3527807845

9783527807826

3527807829

9783527807833

3527807837

OCLC:

964526256