Immunotherapy for Pediatric Malignancies / edited by Juliet C. Gray, Aurélien Marabelle.

Format:

Book

Contributor:

Gray, Juliet C., editor.

Marabelle, Aurélien, editor.

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Immunology.

Oncology.

Pediatrics.

Medicine & Public Health.

Local Subjects:

Medicine & Public Health.

Oncology.

Pediatrics.

Immunology.

Physical Description:

1 online resource (IX, 297 pages 29 illustrations, 27 illustrations in color)

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2018.

System Details:

text file PDF

Summary:

This book provides a comprehensive overview of current immunotherapy strategies, and how these may be applicable to childhood cancers. The first part of the book reviews how the immune system recognizes cancer, and the various escape mechanisms allowing tumour growth. The importance of the tumor microenvironment and the challenges this may present to achieving effective immunotherapy are discussed. Monoclonal antibodies, cellular, cytokine and vaccine therapies are all comprehensively reviewed, with particular focus on their potential application to pediatric cancers. Practical aspects of delivering such therapies to children, likely toxicities and potential biomarkers are considered. Finally, consideration is given to how, in the longer term, such therapies may be combined with conventional therapies such as chemotherapy and radiotherapy. Edited by two distinguished pediatric oncologists with a collection of chapters from the most authoritative experts in cancer immunotherapy, this is an indispensable volume for pediatric oncologists and physicians working in childhood cancer care.

Contents:

Introduction to Pediatric Cancer Immunotherapy

Overcoming immune suppression in the tumor microenvironment: Implications for multi-modal therapy

Allogeneic stem cell transplantation

Overview of monoclonal antibody therapies

Monoclonal Antibodies Targeting Hematological Malignancies

Monoclonal Antibodies Directly Targeting Antigens on Solid Tumours

Monoclonal antibodies targeting the immune system

Adoptive T Cell Therapies for Children's Cancers

NK Cell and NKT Cell Immunotherapy

Cancer Vaccines in Pediatrics

Immune Adjuvants and Cytokine Therapies

Immune biomarkers in pediatric malignancies

Future perspectives.

Other Format:

Printed edition:

ISBN:

9783319434865

Access Restriction:

Restricted for use by site license.