Histiocytic Disorders / edited by Oussama Abla, Gritta Janka.

Format:

Book

Contributor:

Abla, Oussama, editor.

Janka, Gritta, editor.

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Hematology.

Oncology.

Pathology.

Medicine & Public Health.

Local Subjects:

Medicine & Public Health.

Hematology.

Oncology.

Pathology.

Physical Description:

1 online resource (XII, 392 pages 96 illustrations, 74 illustrations in color)

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2018.

System Details:

text file PDF

Summary:

This volume provides a comprehensive and world-class review of the field of histiocytic neoplasms and hemophagocytic lymphohistiocytosis (HLH). It reviews all the advances in the field of histiocytoses during the last ten years, particularly with regards to the genomic findings in LCH and other histiocytic neoplasms and the new suggested classification of the histiocytic disorders. Additionally, it features a state-of-the art update on the most recent treatment strategies for LCH, including the results of the last LCH-III international trial, salvage therapies such as reduced-intensity conditioning (RIC) stem cell transplant (SCT), and targeted therapies with BRAF and MEK inhibitors, as well as the challenging cases of CNS-neurodegenerative LCH and its therapeutic perspectives. For primary and secondary HLH the book updates the most recent genetic and pathophysiological findings, including macrophage-activation syndrome (MAS), and includes a special chapter on HLH in adults. Treatment chapters encompass therapy for newly diagnosed HLH and refractory disease as well as stem-cell transplantation and novel therapies. The text also highlights the most recent advances in the treatment of the uncommon histiocytic disorders, such as Erdheim-Chester disease (ECD), Juvenile xanthogranuloma (JXG) and JXG-like conditions, Rosai-Dorfman disease (RDD), and the very rare malignant histiocytoses. Written by international experts in the field, Histiocytic Disorders is a valuable resource for clinicians, researchers, fellows and residents who are interested in or manage histiocytic disorders in children and adults.

Contents:

Pathology of Histiocytic Disorders and Neoplasms and Related Disorders

Biology and Genomics of LCH and Related Disorders

Epidemiology and Clinical Manifestations of Langerhans Cell Histiocytosis in Children

Central Nervous System Langerhans Cell Histiocytosis

First-line Treatment of Pediatric Langerhans Cell Histiocytosis

Treatment of Relapsed and Refractory Langerhans Cell Histiocytosis in Children

Adult Langerhans Cell Histiocytosis

Late Effects of Langerhans Cell Histiocytosis and the Association of LCH with Malignancy

Classification, Clinical Manifestations and Diagnostics of HLH

CNS involvement in HLH (CNS-HLH)

Genetics and Pathogenesis of Haemophagocytic Lymphohistiocytosis

Hemophagocytic Lymphohistiocytosis Associated with Malignancies and with Epstein Barr Virus

Macrophage Activation Syndrome in Rheumatic Diseases (MAS-HLH)

Treatment of Newly Diagnosed HLH and Refractory Disease

Hematopoietic Cell Transplantation and Novel Therapies in Hemophagocytic Lymphohistiocytosis

HLH in Adults

Juvenile Xanthogranuloma and Related Non-LCH Disorders

Erdheim-Chester Disease

Rosai-Dorfman Disease

Malignant Histiocytoses.

Other Format:

Printed edition:

ISBN:

9783319596327

Access Restriction:

Restricted for use by site license.