The Science and Practice of Lithium Therapy / edited by Gin S. Malhi, Marc Masson, Frank Bellivier.

Format:

Book

Contributor:

Malhi, Gin S., editor.

Masson, Marc, editor.

Bellivier, Frank, editor.

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Neurosciences.

Psychopharmacology.

Chemotherapy.

Medicine & Public Health.

Pharmacotherapy.

Local Subjects:

Medicine & Public Health.

Psychopharmacology.

Pharmacotherapy.

Neurosciences.

Physical Description:

1 online resource (XVI, 342 pages 24 illustrations, 21 illustrations in color.)

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2017.

System Details:

text file PDF

Summary:

This book provides a clear and comprehensive guide to the clinical prescription of lithium that draws upon evidence-based knowledge of its mechanisms of action. The book is divided into two parts, on the science of lithium and the practice of lithium therapy. The former covers aspects such as the properties of the lithium ion, pharmacokinetics and pharmacodynamics, impact on neurotransmission, and gene expression modulation. The section on practice includes discussion of variability in response to lithium, use of lithium in the treatment of bipolar disorders, its value in suicide prevention, administration during pregnancy and in the pediatric age group, and side effects. Lithium is arguably the only true mood stabilizer, and its multifaceted effects across many clinical domains have given rise to a resurgence of interest in recent years, fuelled by both researchers and clinicians. Nevertheless, its use remains constrained by exaggerated concerns about potential side-effects. In reality, lithium is a simple molecule that is relatively straightforward to administer and monitor and has potentially profound benefits at a fraction of the cost of contemporary agents. This book dispels the many myths and concerns that surround its use and will be of interest for clinicians and researchers worldwide.

Contents:

Section I: Science of Lithium: The Ion : Lithium

Pharmacokinetics and pharmacodynamics of lithium

Lithium : neurotransmission and cellular mechanisms pathways underlying neuroprogression in bipolar disorder

Lithium on gene expression modulation

Neuroimaging and lithium

Conclusion: overview of potential mechanisms of action of lithium in bipolar disorder

Section II: Practice of Lithium Therapy

Introduction of lithium in Medicine and Psychiatry

Lithium Response variability

Lithium Response variability: Pharmacogenomics studies

Lithium Response variability: Biomarkers

Lithium in acute and maintenance treatment of bipolar disorders

Lithium and suicide prevention

Lithium in Bipolar disorders international guidelines

Lithium and pregnancy

Lithium in children and adolescents

Short and mid-term side effects of lithium

Lithium, kidneys, renal failure

Lithium intoxication

Discontinuation and re-use of lithium

Conclusion : overview of indications and monitoring of lithium in bipolar disorders.

Other Format:

Printed edition:

ISBN:

9783319459233

Access Restriction:

Restricted for use by site license.