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Translational Anatomy and Cell Biology of Autism Spectrum Disorder / edited by Michael J. Schmeisser, Tobias M. Boeckers.

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Format:
Book
Contributor:
Schmeisser, Michael J., editor.
Boeckers, Tobias M., editor.
SpringerLink (Online service)
Series:
Advances in anatomy, embryology, and cell biology 0301-5556 ; 224.
Advances in Anatomy, Embryology and Cell Biology, 0301-5556 ; 224
Language:
English
Subjects (All):
Medicine.
Neurosciences.
Psychiatry.
Cytology.
Biomedicine.
Cell Biology.
Local Subjects:
Biomedicine.
Neurosciences.
Psychiatry.
Cell Biology.
Physical Description:
1 online resource (VIII, 211 pages 17 illustrations in color.)
Contained In:
Springer eBooks
Place of Publication:
Cham : Springer International Publishing : Imprint: Springer, 2017.
System Details:
text file PDF
Summary:
Autism spectrum disorder (ASD) affects approximately 1 % of the human population and is characterized by a core symptomatology including deficits in social interaction and repetitive patterns of behaviour plus various co-morbidities. Although a lot of progress has been made to uncover underlying causes and mechanisms throughout the last decade, we are still at the very beginning to understand this enormously complex neurodevelopmental condition. This special volume is focused on translational anatomy and cell biology of ASD. International experts from the field including several members of the EU-AIMS initiative launched by the European Union to develop novel treatments for ASD have contributed chapters on several topics covering all crucial aspects of translational ASD research with a special emphasis on ASD model systems including stem cells and animals. Primary objective is to clarify how anatomical and cell biological phenotypes of ASD will help to translate basic mechanisms to clinical practice and to efficiently treat affected individuals in the near future.
Contents:
Anatomy and cell biology of autism spectrum disorder: Lessons from human genetics
Neuroanatomy and neuropathology of autism spectrum disorder in humans
Modelling autistic neurons with induced pluripotent stem cells
Modelling autistic features in mice using quantitative genetic approaches
Behavioural phenotypes and neural circuit dysfunctions in mouse models of autism spectrum disorder
Cerebellar and striatal pathologies in mouse models of autism spectrum disorder
The role of neurotrophic factors in mouse models of autism spectrum disorder: focus on Bdnf and Igf-1
The role of the oxytocin/arginine vasopressin system in animal models of autism spectrum disorder
Extracerebral dysfunction in animal models of autism spectrum disorder
Genetic and pharmacological reversibility of phenotypes in mouse models of autism spectrum disorder.
Other Format:
Printed edition:
ISBN:
9783319524986
Access Restriction:
Restricted for use by site license.

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