Neuroprotective Therapy for Stroke and Ischemic Disease / edited by Paul A. Lapchak, John H. Zhang.

Format:

Book

Contributor:

Lapchak, Paul A., editor.

Zhang, J. H. (John H.), editor.

SpringerLink (Online service)

Series:

Springer series in translational stroke research 2363-958X

Springer Series in Translational Stroke Research, 2363-958X

Language:

English

Subjects (All):

Medicine.

Neurosciences.

Cardiology.

Biomedicine.

Local Subjects:

Biomedicine.

Neurosciences.

Cardiology.

Physical Description:

1 online resource (XVII, 795 pages 105 illustrations, 71 illustrations in color.)

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2017.

System Details:

text file PDF

Summary:

This book is a critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in both academia and industry; it serves to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently, stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. Divided into five sections, the proposed volume explores historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the most recent bench-side research.

Contents:

Reflections on Neuroprotection Research and the Path Toward Clinical Success

Systematic review and meta-analysis: important tools in understanding

Neuroprotection is Technology, not Science

History of Experimental Stroke Research

History of Neuroprotection: Trials and Tribulations

Targeting PSD-95 As a Novel Approach in the Treatment of Stroke

ATP Sensitive Potassium Channels (KATP) Play a Role in Hypoxic Preconditioning against Neonatal Hypoxic-Ischemic Brain Injury

Targeting Oxidative Stress in Stroke

Nitrones, Old Fellows for New Therapies in Ischemic Stroke

Neuroprotective strategies via modulation of innate immune receptors

Harnessing the power of the human immune system via multi-omic immune profiling in stroke treatment and recovery

Polarization of microglia/macrophages in brain ischemia: relevance for stroke therapy

Endoplasmic Reticulum Stress: An Opportunity for Neuroprotective Strategies after Stroke

Effects of Neuroprotectants before and after stroke: Statins and Anti-Hypertensives

Toward Effective Combination Therapy and Pleiotropic Drugs

TRPM7 Channels as Potential Therapeutic Targets for Stroke Cholinergic Protection in Ischemic Brain Injury

Remote Ischemic Conditioning: A Highly Translatable Therapy for Acute Stroke

Hypothermia for Acute Ischemic Stroke

Modern endovascular treatment of ischemic disease

Cerebral Microbleeds and Thrombolysis for Acute Ischemic Stroke

Targeting pericytes and the microcirculation for ischemic stroke therapy

Thrombolytic and Endovascular Therapies for Acute Ischemic Stroke

Sonothrombolysis for acute ischemic stroke: a critical appraisal

Combination Therapy with Thrombolysis

Oxygen Carriers: Are they enough for cellular support?

A new paradigm in protecting ischemic brain: preserving the neurovascular unit before reperfusion

The right rodent for the job: infarct variability between strains and its impact on logistics of experimental animal studies

Rabbit Spinal Cord Ischemia Model for the Development of Neuroprotective Treatments

Stroke Sex Differences: from basic research to clinical trials

Unpuzzling the co-morbid type 2 diabetes and hypertension-related cognitive dysfunction and stroke

Sex Specific Factors in Stroke

Current Imaging Strategies for Patient Selection in Acute Ischemic Stroke Trials.

Other Format:

Printed edition:

ISBN:

9783319453453

Access Restriction:

Restricted for use by site license.