Patient-Derived Xenograft Models of Human Cancer / edited by Yuzhuo Wang, Dong Lin, Peter W. Gout.

Format:

Book

Contributor:

Wang, Yuzhuo, Ph.D., editor.

Lin, Dong, M.D., editor.

Gout, Peter W., editor.

SpringerLink (Online service)

Series:

Molecular and translational medicine 2197-7852

Molecular and Translational Medicine, 2197-7852

Language:

English

Subjects (All):

Medicine.

Oncology.

Medicine & Public Health.

Local Subjects:

Medicine & Public Health.

Oncology.

Physical Description:

1 online resource (XI, 204 pages 27 illustrations, 26 illustrations in color.)

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Humana Press, 2017.

System Details:

text file PDF

Summary:

This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text. Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.

Contents:

Introduction

History and Evolution of PDX Cancer Models

Establishment and Characterization of PDX Models

Methods of Generating PDX Models

Fidelity and Stability of PDX Models

Applications of PDX Models

Studies of Cancer Heterogeneity

PDX and Cancer Stem Cells

Modeling Cancer Metastasis

Modeling Drug Resistance

PDX and Biomarker Development

PDX and Preclinical Drug Screening

Co-clinical Trials and Personalized Cancer Therapy/Precision Medicine

Epilogue

Future Perspective.

Other Format:

Printed edition:

ISBN:

9783319558257

Access Restriction:

Restricted for use by site license.