Chromatin Regulation of Early Embryonic Lineage Specification / edited by Jason Knott, Keith Latham.

Format:

Book

Contributor:

Knott, Jason, editor.

Latham, Keith, editor.

SpringerLink (Online service)

Series:

Advances in anatomy, embryology, and cell biology 0301-5556 ; 229.

Advances in Anatomy, Embryology and Cell Biology, 0301-5556 ; 229

Language:

English

Subjects (All):

Medicine.

Human genetics.

Human physiology.

Cytology.

Biomedicine.

Human Genetics.

Cell Biology.

Human Physiology.

Local Subjects:

Biomedicine.

Human Genetics.

Cell Biology.

Human Physiology.

Physical Description:

1 online resource (VII, 78 pages 16 illustrations in color).

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2018.

System Details:

text file PDF

Summary:

Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages. .

Contents:

CHD1 controls cell lineage specification through zygotic genome activation

Chromatin remodelling proteins and cell fate decisions in mammalian preimplantation development

Transcriptional regulation and genes involved in first lineage specification during preimplantation development

ROCK and RHO playlist for preimplantation development: Streaming to HIPPO pathway and apicobasal polarity in the first cell differentiation

XEN and the art of stem cell maintenance - molecular mechanisms maintaining cell fate and self-renewal in extraembryonic endoderm stem (XEN) cell lines. .

Other Format:

Printed edition:

ISBN:

9783319631875

Access Restriction:

Restricted for use by site license.