Metalloprotein active site assembly / editors, Michael K. Johnson, University of Georgia, Athens, GA, USA, Robert A. Scott, University of Georgia, Athens, GA, USA.

Format:

Book

Contributor:

Sabin W. Colton, Jr., Memorial Fund.

Johnson, Michael K., 1953- editor.

Scott, Robert A., 1953- editor.

Series:

EIBC books

Language:

English

Subjects (All):

Metalloproteins.

Bioinorganic chemistry.

Biochemistry.

Metalloproteins--physiology.

Medical Subjects:

Metalloproteins--physiology.

Physical Description:

xii, 406 pages : illustrations (some color) ; 29 cm.

Place of Publication:

Chichester, West Sussex, UK : John Wiley & Sons Ltd, 2017.

Summary:

"Metalloprotein active site assembly focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved. An excellent companion to the earlier book in this series Metals in Cells--which discussed both the positive and negative effects of cellular interactions with metals--this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research. Metalloprotein active site assembly is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics"--Publisher's website.

Contents:

Nif system for simple [Fe-S] cluster assembly in nitrogen-fixing bacteria / Patricia C. Dos Santos and Dennis R. Dean

Iron-sulfur cluster assembly in bacteria and eukarya using the ISC biosynthesis machinery / Sandrine Ollagnier de Choudens and Hélène Puccio

The suf system in archaea, bacteria, and eukaryotic organelles / Guangchao Dong [and 3 others]

Roles of class II glutaredoxins in the maturation of Fe-S proteins / Jonathan Przybyla-Toscano [and 3 others]

Nitrogenase metallocluster assembly / Nathaniel S. Sickerman [and 3 others]

Metallocluster assembly : maturation of [FeFe]-hydrogenases / Giorgio Caserta [and 3 others]

CO dehydrogenase and acetyl-CoA synthase / Holger Dobbek

Assembly of dinuclear copper center in tyrosinases and hemocyanins / Nobutaka Fujieda and Shinobu Itoh

Multicopper oxidases / Daniel J. Kosman

Assembly of the redox-active metal centers of cytochrome c oxidase / Eva Nyvltova, Antoni Barrientos and Jonathan Hosler

CuA and CuZ center assembly in nitrous oxide reductase / Sofia R. Pauleta and Isabel Moura

MoCu CO dehydrogenase and its active-site assembly / Frank Mickoleit

Homo- and heterometallic dinuclear manganese proteins : active site study / Gustav Berggren, Daniel Lundin and Britt-Marie Sjöberg

Biogenesis and assembly of the CaMnâ‚„Osâ‚ core of photosynthetic water oxidases and inorganic mutants / Colin Gates, Gennady Ananyev and G. Charles Dismukes

Urease activation / Robert P. Hausinger

Insights into [NiFe]-hydrogenase active site metallocluster assembly / Robert Gary Sawers and Constanze Pinske

Moco in Mo/W enzymes / Silke Leimkühler

Heme biosynthesis / Amy E. Medlock and Harry A. Dailey

Siroheme assembly and insertion to nitrite and sulfite reductase / M. Elizabeth Stroupe and Martin J. Warren

Biosynthesis of coenzyme F430 and the posttranslational modification of the active site region of methyl-coenzyme M reductase / Steven O. Mansoorabadi, Kaiyuan Zheng and Phong D. Ngo

Coenzyme B₁₂ biosynthesis in bacteria and archaea / Theodoric A. Mattes [and 3 others]

Crosslinked cys-tyr free radical redox cofactor / James W. Whittaker

Topaquinone biogenesis and lysyl tyrosine quinone biogenesis in Cu amine oxidase / David M. Dooley, Doreen E. Brown and Eric M. Shepard.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Sabin W. Colton, Jr., Memorial Fund.

Other Format:

Online version: Metalloprotein active site assembly.

ISBN:

9781119159834

1119159830

OCLC:

975027699

Publisher Number:

99976871362