The molecular and cellular basis of neurodegenerative diseases : underlying mechanisms / edited by Michael S. Wolfe.

Format:

Book

Contributor:

Wolfe, Michael S., editor.

Language:

English

Subjects (All):

Nervous system--Degeneration--Molecular aspects.

Nervous system.

Nervous system--Degeneration.

Genre:

Electronic books.

Physical Description:

1 online resource

Place of Publication:

London : Academic Press is an imprint of Elsevier, [2018]

System Details:

text file

Summary:

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field.

Contents:

Front Cover; The Molecular and Cellular Basis of Neurodegenerative Diseases; Copyright Page; Dedication; Contents; List of Contributors; Preface; 1 Solving the Puzzle of Neurodegeneration; Introduction: The General Problem of Neurodegeneration; Epidemiology and Clinical Presentation; Molecular Pathology; Genetics; Molecular Clues to Mechanisms of Pathogenesis; Common Themes and Controversies in Neurodegeneration; Animal Models; Prospects for Therapeutics; Conclusions and Perspective; References; 2 Prion Diseases; Introduction and Historical Perspective

3 Alzheimer's Disease: Toward a Quantitative Biological Approach in Describing its Natural History and Underlying MechanismsQuantitative Approach to Basic AD Demographics; Change Over Time: (i) Biogenesis, Production, and Turnover of Aβ; Change Over Time: (ii) The Accumulation, Spread, Propagation of Aβ; Change Over Time: (iii) The Growth and Accumulation of Plaque Cores; Change Over Time: (iv) Brain Atrophy; Change Over Time: (v) Cognition; Clearance Mechanisms and Impaired Phagocytosis; Calculating Polygenic Risk Scores

Mitochondrial Energy ProductionRNA Metabolism; Axonal Dysfunction; Excitotoxicity; Oxidative Stress; Neuroinflammation; Other TDP-43 Proteinopathies; Frontotemporal Dementia; TDP-43 in Alzheimer's Disease and Parkinsonian Syndromes; Inclusion Body Myositis; Conclusions; References; 6 Parkinson's Disease and Other Synucleinopathies; Introduction: The Pathology of Parkinson's Disease; Protein Deposition; Aggregation of α-Synuclein in PD; The Broader Set of Synucleinopathies; Changes in Cellularity; Neuronal Loss; Reactive Gliosis; Genes Associated with Synucleinopathies

Disease-Modifying Strategies: Models of Aβ Accumulation in Alzheimer's Disease-Implications for Aβ Amyloid-Targeting TherapiesReferences; 4 Neurodegeneration and the Ordered Assembly of Tau; Introduction; Tau Isoforms; Tau Aggregation; Genetics of MAPT; Propagation of Tau Aggregates; Strains of Aggregated Tau; Acknowledgments; References; Further Reading; 5 Amyotrophic Lateral Sclerosis and Other TDP-43 Proteinopathies; TDP-43 Biology; Amyotrophic Lateral Sclerosis; ALS-TDP-43; ALS-SOD1; ALS-FUS; ALS-C9ORF72; Mechanisms Dysregulated; Nucleocytoplasmic Transport; Proteostasis Clearance

Molecular Mechanism of Prion PropagationThe Cellular Prion Protein: Structure and Proteolytic Processing; Physiological Function of PrPC; Mechanisms of PrPSc Toxicity: The N-Terminal Domain of PrPC Possess a Toxic Effector Activity; Human Prion Diseases; Animal Prion Diseases; Prion Strains and Species Barriers; Methods for Propagation and Detection of Prions; Therapeutic Approaches; PrPC and the Alzheimer's Aβ Peptide; Prion-like Propagation of Misfolded Proteins in Other Neurodegenerative Diseases; Concluding Remarks; References

Notes:

Includes bibliographical references and index.

Online resource; title from PDF title page (EBSCO, viewed April 6, 2018).

Other Format:

Print version:

ISBN:

9780128113059

0128113057

OCLC:

1030303153

Access Restriction:

Restricted for use by site license.