New therapeutics for traumatic brain injury : prevention of secondary brain damage and enhancement of repair and regeneration / edited by Kim A. Heidenreich.

Format:

Book

Contributor:

Heidenreich, Kim A., editor.

Language:

English

Subjects (All):

Brain damage--Treatment.

Brain damage.

Brain damage--Rehabilitation.

Brain--Wounds and injuries--Complications.

Brain.

Genre:

Electronic books.

Physical Description:

1 online resource (xxv, 325 pages) : illustrations (some color)

Place of Publication:

London : Academic Press is an imprint of Elsevier, [2017]

System Details:

text file

Summary:

"New Therapeutics for Traumatic Brain Injury: Prevention of Secondary Brain Damage and Enhancement of Repair and Regeneration explores traumatic brain injury (TBI), a major cause of death and disability throughout the world. The delayed nature of the secondary injury phase suggests that there is a therapeutic window for pharmacological interventions or other approaches to prevent progressive tissue damage and improve functional outcomes. It is now apparent that therapeutic interventions should entail both protective and repair/regeneration strategies depending on the phase of brain injury. This book describes emerging experimental strategies for the treatment of TBI, including new anti-inflammatory or anti-apoptotic therapeutics that limit brain damage, and novel or repurposed drugs that enhance repair or regeneration of the brain after injury"--Publisher's description.

Contents:

Part I: Interventional therapies for TBI previously or currently in phase 3 clinical trials. Why did the phase III clinical trials for progesterone in TBI fail? An analysis of three potentially critical factors / D.G. Stein, R.B. Howard, I. Sayeed

Hypothermia for traumatic brain injury: current evidence and future directions / H. Mtaweh, D. Simon, M.J. Bell

The future of TBI: hyperbaric oxygen as a primary therapeutic approach / B. Miskin, L.A. Fox

Part II: Repurposing FDA approved drugs for TBI treatment. Erythropoietin and its derivatives: mechanisms of neuroprotection and challenges in clinical translation / T. Bogoslovsky, J.D. Bernstock, K. Kenney, C. Moore, R. Diaz-Arrastia

Atorvastatin in the treatment of traumatic brain injury / A.N. Sen, S.P. Gopinath, C.S. Robertson

The application of glibenclamide in traumatic brain injury / D.S. Hersh, J.M. Simard, H.M. Eisenberg

Perispinal etanercept for traumatic brain injury / E. Tobinick, H. Rodriguez-Romanacce, R. Kinssies, N. Kim

Part III: Interventional drugs for TBI in phase 1-2 clinical trials. Nitric oxide synthase inhibitors in traumatic brain injury / R. Schinzel, F. Tegtmeier

Management of paroxysmal sympathetic hyperactivity after traumatic brain injury / L.D. Wilson, T.C. Leath, M.B. Patel

Part IV: Interventional drugs for TBI in preclinical development. The use of estrogen for the treatment of traumatic brain injury / W.J. Hubbard, I.H. Chaudry

Voltage-gated calcium channel blockers for the treatment of traumatic brain injury / G.G. Gurkoff, K. Shahlaie, B.G. Lyeth, R.F. Berman

5-lipoxygenase-activating protein inhibitors: promising drugs for treating acute and chronic neuroinflammation following brain injury / K.A. Heidenreich, C.E. Corser-Jensen

Carbonyl scavenging as an antioxidant neuroprotective strategy for acute traumatic brain injury / J.E. Cebak, I.N. Singh, J.A. Wang, R.L. Hill, J.R. Kulbe, E.D. Hall

TrkB receptor agonist 7,8-Dihydroxyflavone and its therapeutic potential for traumatic brain injury / J. Romeika, M. Wurzelmann, D. Sun

Ceftriaxone treatment of TBI / M.Q. Hameed, A. Rotenberg

Part V: Drugs for TBI rehabilitation. Memantine: a safe and tolerable NMDA antagonist with potential benefits in traumatic brain injury / M.A. Keiski

Interventional drugs for TBI Rehabilitation of cognitive impairment: the cholinesterase inhibitor rivastigmine / M.A. Hernandez-Tejada, O. Brawman-Mintzer

Docosahexaenoic acid and omega 3 fatty acids / M.E. Schober

Treatment of mood disorders following traumatic brain injury / H.L. Lin, R.E. Jorge

Notes:

Includes bibliographical references and index.

Description based on online resource; title from electronic title page (ScienceDirect viewed March 27, 2018).

Other Format:

Print version: New therapeutics for traumatic brain injury.

ISBN:

9780128027011

0128027010

OCLC:

959618098

Access Restriction:

Restricted for use by site license.