Iron oxide nanoparticles for biomedical applications : synthesis, functionalization and application / editors, Morteza Mahmoudi, Sophie Laurent.

Format:

Book

Contributor:

Mahmoudi, Morteza, 1979- editor.

Series:

Metal oxides series

Language:

English

Subjects (All):

Nanomedicine.

Medical Subjects:

Nanomedicine.

Physical Description:

xvii, 315 pages ; 23 cm.

Place of Publication:

Amsterdam, Netherlands ; Cambridge, MA : Elsevier, [2018]

Summary:

Iron oxide nanoparticles are likely to prove key to the development of enhanced biomedical imaging technology due to their magnetic properties. However, in order to take advantage of those properties, it is necessary to pin down processes for synthesis and stablization of this nanomaterial. Iron Oxide Nanoparticles for Biomedical Applications offers thorough coverage of these processes with a view to clearing the path toward full commercialization of iron oxide nanoparticles, and outlines their existing and future applications in biomedicine. Iron Oxide Nanoparticles for Biomedical Applications begins with chapters covering the synthesis, stabilization, physicochemical characterization, and functionalization of iron oxide nanoparticles. The second part of the book outlines the various biomedical imaging applications that currently or potentially take advantage of the magnetic properties of iron oxide nanoparticles. Close attention is given to potential iron oxide-based therapies, and drug delivery, cancer therapy and tumor-targeted therapy are discussed. This comprehensive book is an essential reference for all those academics and professionals who require thorough knowledge of recent and future developments in the role of iron oxide nanoparticles in biomedicine. Unlocks the potential of iron oxide nanoparticles to transform diagnostic imaging techniques. Full coverage of new developments and recent research make this essential reading for researchers and engineering alike. Explains the synthesis, processing and charcterization of iron oxide nanoparticles with a view to their use in biomedicine. Book jacket.

Contents:

Part 1 Iron Oxide Nanoparticles 1

1 Metal Oxide Particles and Their Prospects for Applications / S. Laurent Laurent, S., S. Boutry Boutry, S., R.N. Muller Muller, R.N. 3

1.1 Magnetic Metal Oxides 7

1.2 Metal Oxides With Photoluminescence Properties 9

1.3 Metal Oxides in Electronics, Catalysis, Gas Sensors and Energy Technologies 10

1.4 Metal Oxides in Biomedical Applications 17

References 27

Further Reading 42

2 Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization, and Application / G. Cotin Cotin, G., S. Plant Plant, S., D. Mertz Mertz, D., D. Felder-Flesch Felder-Flesch, D., S. Begin-Colin Begin-Colin, S. 43

2.1 Iron Nanoparticles: Advantages and Limitations for Biomedical Applications 43

2.2 Synthesis of Iron Oxide Nanoparticles Almed for Biomedical Applications 48

2.3 Stabilization of the Nanosystems 61

2.4 Methods of IONPs Functionalization for Biomedical Applications 71

References 76

Part 2 Biomedical Applications 89

3 Protein Corona: The Challenge at the Nanobiointerfaces / S. Zanganeh Zanganeh, S., J.Q. Ho Ho, J.Q., M. Aieneravaie Aieneravaie, M., M. Erfanzadeh Erfanzadeh, M., R. Spitler Spitler, R. 91

3.1 Introduction 91

3.2 The Protein Corona 93

3.3 "Hard" Versus "Soft" Corona 97

3.4 Reversible Versus Irreversible Interactions Between NPs and Protein 97

References 99

4 Nano cytotoxicity / S. Zanganeh Zanganeh, S., R. Spitler Spitler, R., M. Erfanzadeh Erfanzadeh, M., J.Q. Ho Ho, J.Q., M. Aieneravaie Aieneravaie, M. 105

4.1 Introduction 105

4.2 Cytotoxicity 106

4.3 Superparamagnetic Iron Oxide Nanoparticles 109

References 112

5 Magnetic Particle Imaging (MPI) / S. Zangane Zangane, S., M. Aieneravaie Aieneravaie, M., M. Erfanzadeh Erfanzadeh, M., J.Q. Ho Ho, J.Q., R. Spitler Spitler, R. 115

5.1 Introduction 115

5.2 Superparamagnetic Iron Oxide Nanoparticles for MPI 116

5.3 Size and Homogeneity 117

5.4 Iron Oxide Nanoparticle Coatings 126

References

6 Targeted Iron Oxide (Nano)particles Used as MRI Contrast Agent in Small Animal Models / S. Boutry Boutry, S., R.N. Muller Muller, R.N., S. Laurent Laurent, S. 135

6.1 Introduction 135

6.2 MRI of Apoptosis With Iron Oxide-Based Compounds 135

6.3 MRI of Inflammatory Diseases With Iron Oxide-Based Compounds 139

6.4 MRI of Tumor Angiogenesis With Iron Oxide-Based Compounds 147

References 158

7 Dual-Modality Imaging / A. Lahooti Lahooti, A., S. Shanehsazzadeh Shanehsazzadeh, S., S. Laurent Laurent, S. 165

7.1 The Necessity of Dual Modality imaging 165

7.2 Molecular Imaging 167

7.3 Muitimodality Imaging 168

7.4 PET/MRI 172

7.5 Advantages 173

7.6 Challenges in PET/MRI 174

8 Current Outlook and Perspectives on Nanoparticle-Mediated Magnetic Hyperthermia / C. Blanco-Andujar Blanco-Andujar, C., F.J. Teran Teran, F.J., D. Ortega Ortega, D. 197

8.1 Historical Development and Outlook 197

8.2 Rationalization of NP Characteristics for MH 202

8.3 Interparticle Interactions 208

8.4 Justification for the Use of Iron Oxides in Magnetic Hyperthermia 210

8.5 Other Materials Used and Envisioned for Magnetic Hyperthermia 214

8.6 Overview on the Current Instrumentation Available 220

8.7 Clinical Trials (Past, Present, and Future Ones) 224

8.8 Other Selected Topics in Magnetic Hyperthermia Research 227

8.9 Conclusions and Prospects 230

Acknowledgments 232

References 233

9 Drug Delivery / S. Zanganeh Zanganeh, S., J.Q. Ho Ho, J.Q., M. Aieneravaie Aieneravaie, M., M. Erfanzadeh Erfanzadeh, M., M. Pauliah Pauliah, M., R. Spitler Spitler, R. 247

9.1 Introduction 247

9.2 Iron Oxide Nanoparticles: Design Considerations 252

9.3 In Vivo Barriers 253

9.4 Physicochemical Considerations 254

9.5 Hydrodynamic Size 254

9.6 Shape 255

9.7 Surface Properties 255

9.8 Directing Nanoparticles In Vivo 256

9.9 Drug Loading and Release 259

9.10 Toxicity 261

9.11 Coating of SPIONs 261

References 263

10 Tumor-Targeted Therapy / M. Pauliah Pauliah, M., S. Zanganeh Zanganeh, S., M. Erfanzadeh Erfanzadeh, M., J.Q. Ho Ho, J.Q. 273

10.1 Introduction 273

10.2 Nanotechnology and Cancer Therapy 274

10.3 Iron Oxide Nanoparticles and Cancer Therapy 279

10.4 Conclusion 284

References 284

11 Cancer Therapy / S. Zanganeh Zanganeh, S., J.Q. Ho Ho, J.Q., R. Spitler Spitler, R., T. Jafari Jafari, T., N. Khakpash Khakpash, N., M. Erfanzadeh Erfanzadeh, M., M. Pauliah Pauliah, M. 291

11.1 Introduction 291

11.2 The Role of Magnetic Iron Oxide in Cancer Therapy 292

11.3 Diagnostic Imaging and Cancer Therapy 295

11.4 Conclusion 301

References 302.

ISBN:

9780081019252

0081019254

OCLC:

1030801882