Models of seizures and epilepsy / Asla Pitkänen, Paul S. Buckmaster, Aristea S. Galanopoulou, Solomon L. Moshé.

Format:

Book

Contributor:

Pitkänen, Asla, editor.

Buckmaster, Paul S., editor.

Galanopoulou, Aristea S., 1965- editor.

Moshé, Solomon L., editor.

Language:

English

Subjects (All):

Epilepsy.

Spasms.

Epilepsy--Animal models.

Genre:

Electronic books.

Physical Description:

1 online resource (xxvi, 1151 pages)

Edition:

Second edition.

Place of Publication:

London, United Kingdom : Elsevier : Academic Press, [2017]

System Details:

text file

Contents:

Cover; Title page; Copyright page; Contents; Contributors; Foreword; References; Preface; Part I

Introduction; Chapter 1

What Can We Model?; Animal models of seizures; Animal models of epilepsy; A way forward; References; Chapter 2

Comparative Biology and Species Effects on Expression of Epilepsy; Introduction; How does epilepsy vary across species?; Conservative brain evolution; Vertebrate Phylogeny; Similarities Across Vertebrate Brains; Brain size; Brain Size Affects Circuitry; Mechanisms of brain evolution; Invasion; Loss of Connections; Parcellation; Ontogenetic Buffers

Axon DisplacementConcerted and Mosaic Brain Evolution; Tool for Comparing Developmental Stages Across Species; Evolution of the neocortex and hippocampus; Eversion of the Teleost Telencephalon; Amphibian Dorsal Pallium; Reptilian Dorsal Pallium; Dorsal Ventricular Ridge of Reptiles and Birds; Mammalian Neocortex; Pyramidal Cell Evolution; Neocortical Areas; Thalamus; Hippocampal Evolution; Epilepsy-Relevant Species-Specific Hippocampal Characteristics; Conclusions; Acknowledgments; References; Chapter 3

Strain Effects on Expression of Seizures and Epilepsy; Introduction

Mouse strain effects on expression of seizures and epilepsyMouse Models of Acute Seizures and Seizure Susceptibility; Physically-Induced Seizures; Chemically-Induced Seizures; Antiseizure Drugs; The 6-Hz Psychomotor Seizure Model of Partial Epilepsy in Mice; Mouse Strain Differences in Occurrence of Spike-Wave Discharges; The Pilocarpine Model of Temporal Lobe Epilepsy in Mice; The Kainate Model of Temporal Lobe Epilepsy in Mice; The Intrahippocampal Kainate Model of Temporal Lobe Epilepsy in Mice; The Electrical Kindling Model of Temporal Lobe Epilepsy in Mice

The Flurothyl Kindling Mouse Model of Primary Generalized EpilepsiesThe Theiler's Virus Mouse Model of Encephalitis-Induced Temporal Lobe Epilepsy; Rat strain effects on expression of seizures and epilepsy; The Pilocarpine Model of Temporal Lobe Epilepsy in Rats; The Electrical Kindling Model of Temporal Lobe Epilepsy in Rats; Sustained Stimulation of the Basolateral Amygdala in Rats as a Model of Temporal Lobe Epilepsy; Rat Strain Differences in Occurrence of Spike-Wave Discharges or Other EEG Alterations

Dissection of genes that may underlie differences in expression of seizures or epilepsySignal-Recognition-Particle Assembly 9 (Srp9); Potassium Voltage-Gated Channel Subfamily J Member 10 (Kcnj10); Multiple PDZ Domain Crumbs Cell Polarity Complex Component (Mpdz); Cholinergic Receptor Genes; Conclusions; Acknowledgments; References; Further Reading; Chapter 4

Good Welfare Practice in Modeling Seizures and Epilepsy; General description; Background; Ethics and animal research; Legal Framework; NC3Rs report on welfare in rodent epilepsy models; Intrinsic features of epilepsy models; Seizures

Notes:

Vendor-supplied metadata.

Includes bibliographical references and index.

ISBN:

9780128040676

012804067X

OCLC:

990802656

Access Restriction:

Restricted for use by site license.