Biometals in neurodegenerative diseases : mechanisms and therapeutics / edited by Anthony R. White, Michael Aschner, Lucio G. Costa, Ashley I. Bush.

Format:

Book

Language:

English

Subjects (All):

Metals in the body.

Nervous system--Degeneration.

Nervous system.

Metals--Physiological effect.

Metals.

Neurodegenerative Diseases--physiopathology.

Nervous System--chemistry.

Trace Elements--pharmacology.

Medical Subjects:

Neurodegenerative Diseases--physiopathology.

Nervous System--chemistry.

Trace Elements--pharmacology.

Genre:

Electronic books.

Physical Description:

1 online resource

Place of Publication:

London, United Kingdom : Academic Press is an imprint of Elsevier, 2017.

System Details:

text file

Contents:

Cover; Title page; Copyright page; Contents; Contributors; Preface; Chapter 1

Biometals and Alzheimer's Disease; Introduction; The Role of Copper in AD; The Role of Zinc in AD; The Role of Iron in AD; Therapeutic Targeting of Biometals in AD; Conclusions; References; Chapter 2

Copper in Alzheimer's Disease; Introduction; The Physiology of Copper; Copper Absorption and Distribution; Copper in the Liver; Copper's Path From General Circulation to the Brain; The Key Role of Ceruloplasmin; Copper Toxicity; The Role of Copper in Alzheimer's Disease; Genetics of Copper and AD

The AD Copper SubtypeConclusions; References; Chapter 3

The Role of Selenium in Neurodegenerative Diseases; Introduction; Selenoproteins and the Selenoproteome; Selenium and Alzheimer's Disease; Parkinson's Disease; Other Neurodegenerative Diseases; Conclusions; References; Chapter 4

Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response?; Iron; Hemochromatosis; Discovery; Types; HFE; Structure; Function; Polymorphisms; Macrophages; Macrophage and Iron Metabolism; Macrophage Polarization; Macrophages and HFE; HFE and Neurodegenerative Diseases

Alzheimer's DiseaseAmyotrophic Lateral Sclerosis; Parkinson's Disease; HFE and Cancer; HFE Animal Models; Conclusions; References; Chapter 5

Chemical Elements and Oxidative Status in Neuroinflammation; Introduction; Metal-Induced Neurotoxicity and Multiple Sclerosis; Metals and Oxidative Status in Multiple Sclerosis; Metals and Oxidative Status in Clinically Isolated Syndromes; Conclusions; References; Chapter 6

Metals and Neuroinflammation; Introduction; Mechanisms by Which Metal Elements Can Incite Immune Activity; Metals as Haptens; Metal Elements with Valence Instability; Copper (Cu)

Iron (Fe)Manganese; Metals Attaching to Sulfhydryl Residues; Lead (Pb); Mercury (Hg); Metals Associated with Particulate and Colloidal Materials; Aluminum (Al); Titanium, Silver and Gold (Ti, Ag, Au); Metals Which Lead to Oxidative Stress and Inflammation by Means that are not yet Understood; The Relation Between Reactive Oxygen and Nitrogen Species and Inflammation; Conclusions; References; Chapter 7

Metals and Prions: Twenty Years of Mining the Awe; Prion Diseases; Prion Protein; Prion Protein Function; Copper and PrP; Zinc and PrP; Iron and PrP; Manganese and PrP; Metals in Prion Disease

Chelation Therapy and Prion DiseaseConclusions; References; Chapter 8

Manganese and Neurodegeneration; Background; Mn Essentiality and Metabolic Functions; Mn Biokinetics and Homeostatic Control; Routes and Sources of Mn Exposure; Absorption of Airborne Mn; Parenteral Exposure to Mn; Oral Absorption of Mn From Food and Water; Mn Biodistribution and Elimination; Biokinetics of Mn in Brain; Mn Transport Into Brain; Regional Delivery of Mn in the Brain; Mn Elimination From Brain Compartment; Subcellular Distribution of Mn in Brain; Homeostatic Control of Mn

Notes:

Includes index.

Print version record.

Includes bibliographical references and index.

ISBN:

9780128045633

0128045639

OCLC:

985759446

Publisher Number:

40027219848

Access Restriction:

Restricted for use by site license.